ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Chloropyridine 6-Chloropicolinic acid

6-Chloropicolinic acid

6-Chloropicolinic acid Basic information
Product Name:6-Chloropicolinic acid
Synonyms:OTAVA-BB BB5110090024;6-CHLORO-2-PYRIDINECARBOXYLIC ACID;6-CHLORO-2-PICOLINIC ACID;6-CHLOROPICOLINIC ACID;6-CHLOROPYRIDINE-2-CARBOXYLIC ACID;2-CHLORO-6-PYRIDINECARBOXYLIC ACID;2-CHLOROPYRIDINE-6-CARBOXYLIC ACID;2-Pyridinecarboxylicacid,6-chloro-
CAS:4684-94-0
MF:C6H4ClNO2
MW:157.55
EINECS:628-517-2
Product Categories:Picolinic acid series;Carboxylic Acids;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Carboxylic Acids;blocks;Carboxes;Pyridines;Pyridine;pyridine derivative;Organic acids;4684-94-0
Mol File:4684-94-0.mol
6-Chloropicolinic acid Structure
6-Chloropicolinic acid Chemical Properties
Melting point 190-191°C
Boiling point 241.15°C (rough estimate)
density 1.3768 (rough estimate)
refractive index 1.5870 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol
form Crystalline Powder
pka3.27±0.10(Predicted)
color White to cream to tan
Water Solubility 3.40g/L(temperature not stated)
λmax294nm(EtOH)(lit.)
BRN 115849
InChIKeyZLKMOIHCHCMSFW-UHFFFAOYSA-N
CAS DataBase Reference4684-94-0(CAS DataBase Reference)
EPA Substance Registry System6-Chloropicolinic acid (4684-94-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 2
RTECS TJ7535000
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
ALFA English
6-Chloropicolinic acid Usage And Synthesis
Chemical PropertiesOff-white Plates
Uses6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.
6-Chloropicolinic acid Preparation Products And Raw materials
Preparation Products6-Aminopyridine-2-carboxylic acid-->2-Amino-6-methoxy-3-nitropyridine-->2-Amino-6-methoxypyridine-->2-chloro-6-(4-methylpiperidine-1-carbonyl)pyridine-->2-Pyridinecarboxylicacid,6-(1,1-dimethylethoxy)-(9CI)-->2-(6-Chloropyridin-2-yl)ethanaMine
6-CHLOROPYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER 6-Chloropicolinic acid pyridinium Chlorochromate Ethyl 2-(Chlorosulfonyl)acetate 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine 2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-, isooctyl ester Clopyralid (2-hydroxyethyl)ammonium Tetrachloropyridine-2-carboxylic acid 2,5-PYRIDINEDICARBOXYLIC ACID Clopidol METHYL 3,4,5,6-TETRACHLOROPYRIDINE-2-CARBOXYLATE Quinolinic acid CARBOXYLIC ACID Picloram 5-CHLOROPICOLINIC ACID 3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID 2-Chloropyridine
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