1-Methylindole-3-carboxaldehyde

1-Methylindole-3-carboxaldehyde Basic information
Product Name:1-Methylindole-3-carboxaldehyde
Synonyms:TIMTEC-BB SBB010057;RARECHEM AH BS 0121;1 METHYLINDOLE-3-ALDEHYDE;1-METHYLINDOLE-3-CARBALDEHYDE;1-METHYLINDOLE-3-CARBOXALDEHYDE;1-METHYL-1H-INDOLE-3-CARBOXALDEHYDE;AKOS JY2082515;N-Methylindole-3-Carboxaldehyde
CAS:19012-03-4
MF:C10H9NO
MW:159.18
EINECS:242-750-3
Product Categories:Heterocycle-Indole series;Heterocycles;Building Blocks;Heterocyclic Building Blocks;Indoles;Indoles and derivatives;Indole;Heterocyclic Compounds;ALDEHYDE
Mol File:19012-03-4.mol
1-Methylindole-3-carboxaldehyde Structure
1-Methylindole-3-carboxaldehyde Chemical Properties
Melting point 70-72 °C (lit.)
Boiling point 186-189 °C(Press: 3-4 Torr)
density 1.10±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystalline Powder and Chunks
color Light yellow to orange or brown
Water Solubility Insoluble in water.
Sensitive Air Sensitive
BRN 121302
CAS DataBase Reference19012-03-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
1-Methyl-1H-indole-3-carbaldehyde English
SigmaAldrich English
ACROS English
ALFA English
1-Methylindole-3-carboxaldehyde Usage And Synthesis
Chemical Propertieslight yellow to orange or brown crystalline powder
UsesReactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents.
Uses1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).
Synthesis Reference(s)Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960
General Description1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.
1-ETHYL-1H-INDOLE-3-CARBALDEHYDE Methyl 1,2,3,9-TETRAHYDRO-4H-9-METHYL-CARBAZOLE-4-ONE GR 65630, [N-METHYL-3H]- Ethyl 5-acetyloxy-1,2-dimethylindole-3-carboxylate Ondansetron hydrochloride 5-METHYLINDOLE-3-CARBOXALDEHYDE, N-BOC PROTECTE 5-FLUORO-1-METHYLINDOLE-3-CARBOXALDEHYDE 1-Methyl-2-phenylindole-3-carboxaldehyde 5-HYDROXY-2-METHYL-1-PHENYL-1H-INDOLE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate WIN 55,212-2 MESYLATE WIN 55,212-2[5,7-NAPHTHYL-3H]- AKOS B006681 1-METHYLINDOLE-2-CARBOXALDEHYDE 97 6-METHYLINDOLE-3-CARBOXALDEHYDE, N-BOC PROTECTE FK 888 TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.