CYCLO (ARG-GLY-ASP-D-PHE-LYS)

CYCLO (ARG-GLY-ASP-D-PHE-LYS) Basic information

Product Name:	CYCLO (ARG-GLY-ASP-D-PHE-LYS)
Synonyms:	CYCLO(-RGDFK);CYCLO (ARG-GLY-ASP-D-PHE-LYS);cyclo (Arg-Gly-Asp-Phe-Lys);Cyclic RGDFK peptide;Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl);Cyclo(-Arg-Gly-Asp-D-Phe-Lys) Trifluoroacetate salt;c(RGDfK);Cyclo (-RGDfK) TFA
CAS:	161552-03-0
MF:	C27H41N9O7
MW:	603.67
EINECS:
Product Categories:	peptide;RGD
Mol File:	Mol File

CYCLO (ARG-GLY-ASP-D-PHE-LYS) Chemical Properties

Melting point	191℃ (decomposition)
density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O
form	Powder
pka	4.01±0.10(Predicted)

Safety Information

MSDS Information

CYCLO (ARG-GLY-ASP-D-PHE-LYS) Usage And Synthesis

Uses	Cyclo (-RGDfK) Trifluoroacetic Acid Salt is a potent inhibitor of αvβ3 integrin. Used in tumor therapy due to the targeting of the VEGFR2 gene by sRNA.
Biological Activity	in one study where this peptide was labeled with 125i, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. the integrin alpha(iib)beta(3)-specific cyclic hexapeptide contains an arg-gly-asp (rgd) sequence.
target	Integrin

CYCLO (ARG-GLY-ASP-D-PHE-LYS) Preparation Products And Raw materials

Raw materials

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