|
| | Isobutyrophenone Basic information |
| Product Name: | Isobutyrophenone | | Synonyms: | PHENYL ISOPROPYL KETONE;Isobutyrophenone 97%;ALPHA-METHYLPROPIOPHENONE;2-METHYL-1-PHENYL-1-PROPANONE;ISOBUTYROPHENONE;ISOBUTYRYLBENZENE;Isobutyrophenone, 97% 25GR;ISOPROPYL PHENYL KETONE FOR SYNTHESIS | | CAS: | 611-70-1 | | MF: | C10H12O | | MW: | 148.2 | | EINECS: | 210-275-0 | | Product Categories: | | | Mol File: | 611-70-1.mol |  |
| | Isobutyrophenone Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29143900 |
| | Isobutyrophenone Usage And Synthesis |
| Chemical Properties | clear colorless to very slightly yellow liquid | | Uses | Isobutyrophenone is used as an internal standard in the determination of hydroxyzine hydrochloride and benzyl alcohol in injection solutions. It is also used in the preparation of alpha-hydroxyisobutyrophenone. Isobutyrophenone is employed as photosensitizer intermediate. It can react with bromoacetic acid ethyl ester to get 3-hydroxy-4-methyl-3-phenyl-valeric acid ethyl ester. | | Preparation | Isobutyrophenone synthesis: Benzene underwent a Friedel–Crafts acylation with isobutyryl chloride to synthesize isobutyrophenone. The reaction was performed using excess benzene as a replacement for a typical solvent and heat to reflux (88 °C) for a period of 3 hours. Any unreacted benzene was recovered after the reaction during the distillation process. A 66 % yield of isobutyrophenone was obtained from the solar synthesis, compared to a 44 % yield from an in-lab, electrical heating analysis.
 | | Synthesis Reference(s) | Journal of the American Chemical Society, 71, p. 1061, 1949 DOI: 10.1021/ja01171a084
The Journal of Organic Chemistry, 32, p. 404, 1967 DOI: 10.1021/jo01288a032
Tetrahedron Letters, 14, p. 2491, 1973 | | Flammability and Explosibility | Nonflammable |
| | Isobutyrophenone Preparation Products And Raw materials |
|
