D-Mannose

D-Mannose Basic information
Description References
Product Name:D-Mannose
Synonyms:DL-allo-2,3,4,5,6-Pentahydroxy-hexanal;d-[1,2,3-13C3]Mannose;d-[1-12C]Mannose (13C depleted at C1);d-[1-13C:1-2H]Mannose;d-[1-18O]Mannose;d-[2,3,4,5,6-13C5]Mannose;d-[3,4-13C2]Mannose;d-[UL-12C6]Mannose (13C depleted)
CAS:3458-28-4
MF:C6H12O6
MW:180.16
EINECS:222-392-4
Product Categories:Sugars, Carbohydrates & Glucosides;Carbohydrates;13C & 2H Sugars;Basic Sugars (Mono & Oligosaccharides);Biochemistry;Sugars;Dextrins、Sugar & Carbohydrates;Carbohydrates & Derivatives;carbohydrate;bc0001;3458-28-4;Glycon Biochem
Mol File:3458-28-4.mol
D-Mannose Structure
D-Mannose Chemical Properties
Melting point 133-140 °C(lit.)
alpha 14 º (589nm, c=10, H2O)
Boiling point 232.96°C (rough estimate)
density 1,539 g/cm3
refractive index 1.5730 (estimate)
storage temp. room temp
solubility H2O: 50 mg/mL
form powder
pka12.08(at 25℃)
color White
optical activity[α]20/D +13.8±0.5°, 24 hr, c = 10% in H2O
Water Solubility 2480 g/L (17 ºC)
λmaxλ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Sensitive Hygroscopic
Merck 14,5747
BRN 1564373
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKeyWQZGKKKJIJFFOK-ATJJXCEKSA-N
LogP-2.71 at 25℃
CAS DataBase Reference3458-28-4(CAS DataBase Reference)
NIST Chemistry ReferenceD-Mannose(3458-28-4)
EPA Substance Registry SystemD-Mannose (3458-28-4)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
3
TSCA Yes
HS Code 29400010
MSDS Information
ProviderLanguage
D-(+)-Mannose English
ACROS English
SigmaAldrich English
ALFA English
D-Mannose Usage And Synthesis
DescriptionD-Mannose is a nutritional supplement that can be found in cranberries, peaches, apples, other berries, and some plants. D-mannose is a sugar that has an important role in human metabolism, especially in the glycosylation of certain proteins. D-mannose functionalizes by the inhibition of bacterial adherence to uroepithelial cells.
More than 90 percent of recurrent urinary tract infections (UTIs) are caused by Escherichia coli (E. coli), which is normally found in the intestinal tract. The cell walls of each E. coli are covered with tiny fingerlike projections called fimbria. Mannose can bind to the lectin on the bacteria’s fimbria so that the bacteria can be effectively rinsed out by urination.
D-Mannose is by far the most effective supplement for both treatment and prevention of UTIs. And it is used for the treating carbohydrate-deficient glycoprotein syndrome, an inherited metabolic disorder.

References[1] http://www.webmd.com
[2] Bojana Kranjcˇec, Dino Papesˇ , Silvio Altarac (2013) D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial, World J Urol, 32, 79-84
Chemical PropertiesWhite crystalline powder
UsesD-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in inf ant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule.
UsesIt has been used in a study to assess the synthesis of a family of amphiphilic glycopolymers. It has also been used in a study to investigate the early detection of bronchiolitis obliterans after lung transplantation.
UsesD-mannose acts as an alternative energy source utilized by brain. It is used in the study of assessing the synthesis of amphiphilic glycopolymers and investigating early detection of bronchiolitis obliterans.It may be useful in the treatment of urinary tract infections (UTIs) and carbohydrate-deficient glycoprotein syndrome type 1b. It is also useful in the formation of glycan structure and glycosylation.
ApplicationD-mannose is a simple sugar structurally related to glucose. It is absorbed slowly from the gastrointestinal tract, and then a large proportion of it is excreted into the urine.
D-(+)-Mannose has been used:
as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersa
as a medium component for the selection of P898012 sorgum seeds transfected with Agrobacterium
in segmented filamentous bacterium (SFB) medium supplement for culturing human cell lines
Mannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration. Majority of mannose is synthesised from its epimer glucose. It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.
DefinitionChEBI: D-Mannopyranose having alpha-configuration at the anomeric centre.
General DescriptionMannose is a monosaccharide.
Flammability and ExplosibilityNotclassified
Biochem/physiol ActionsMannose, a six-carbon carbohydrate, is the C-2 epimer of glucose and a critical sugar for protein glycosylation. Mannose can also be utilized by the brain as an alternative energy source.
SourceD-mannose is a sugar that can be found in some fruits and vegetables, such as oranges, apples, peaches, broccoli and green beans. It has been used in the past to treat UTIs in animals. Now, there is some interest into whether it could also treat and prevent UTI in humans.
D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It’s metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won’t interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.
Purification MethodsCrystallise -D(+)-mannose repeatedly from EtOH, aqueous 80% EtOH, AcOH or MeOH/propan-2-ol and then dry it in vacuo over P2O5 at 60o. [For 1H NMR and equilibr
D-Mannose-6-13C BETA-D-GLCNAC-[1->6]-ALPHA-D-MAN-1->OME D-MANNONICAMIDE Calcium Alginate Methyl 3-O-(α-D-Mannopyranosyl)-α-D-Mannopyranoside D-MANNONO-1,4-LACTONE 6-BROMO-2-NAPHTHYL-ALPHA-D-MANNOPYRANOSIDE METHYL 2,3-O-ISOPROPYLIDENE-ALPHA-D-MANNOPYRANOSIDE 1,2,3,4,6-Penta-O-acetyl-b-D-mannopyranose 2,3:5,6-DI-O-CYCLOHEXYLIDENE-D-MANNOLACTONE, 98 ALPHA-D-MAN-[1->2]-ALPHA-D-MAN-1->OME 1-NAPHTHYL-ALPHA-D-MANNOPYRANOSIDE D-MANNOSE 6-PHOSPHATE DISODIUM,d-Mannose, 6-(dihydrogen phosphate), disodium salt Methyl 2-O-Allyl-3-O-(2346tetra-O-acetyl-a- D-mannopyranosyl)-a-D-mannopyranoside TATM D-mannose 6-phosphate monosodium,SODIUM MANNOSE PHOSPHATE METHYL-ALPHA-D-MANNOPYRANOSIDE P-AMINOPHENYL ALPHA-D-MANNOPYRANOSIDE

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