1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose

1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Basic information
Synthesis
Product Name:1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose
Synonyms:1,2:5,6-Di-O-isopropylidene-alpha-D-allo;1,2:5,6-Di-O-isoprop;1,2:5,6-Di-O-isopropylidene-α-D-allofuranose ,98%;1,2:5,6-Bis-O-(1-Methylethylidene)-α-D-allofuranose;1,2:5,6-Diacetone-D-allofuranose;Diacetone-D-allofuranose;1,2:5,6-Di-O-isopropylidene-alpha-D-ribo-hexofuranose;1,2:5,6-bis-O-(1-Methylethylidene)-alpha-D-Allofuranose
CAS:2595-05-3
MF:C12H20O6
MW:260.28
EINECS:
Product Categories:13C & 2H Sugars;Allose;Biochemistry;O-Substituted Sugars;Sugars;Carbohydrates & Derivatives;Sugars, Carbohydrates & Glucosides;Carbohydrate Synthesis;Monosaccharides;Specialty Synthesis
Mol File:2595-05-3.mol
1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Structure
1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Chemical Properties
Melting point 73-76 °C(lit.)
alpha 37.5 º (c=1,chloroform)
Boiling point 363.54°C (rough estimate)
density 1.2377 (rough estimate)
refractive index 36.5 ° (C=1, CHCl3)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility almost transparency in Toluene
pka13.15±0.60(Predicted)
form Powder
color White to off-white
Stability:Acid Sensitive
InChIKeyKEJGAYKWRDILTF-BHRXDNSCSA-N
CAS DataBase Reference2595-05-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36/37-26
WGK Germany 3
21
HS Code 29400090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Usage And Synthesis
SynthesisAnhydrous DMSO (650 mL) was cooled to 18−20 °C under nitrogen in a 3-L roundbottomed glass flflask. DMSO solidififies at 18 °C and therefore it is important to keep the reaction mixture just above freezing point. To this cold solution was added P2O5 (142 g, 1.0 mol, 1 equivalent) in 3 portions under a N2 atmosphere. The addition of P2O5 to DMSO is exothermic, and if the mass temperature exceeds 28 °C, the color darkens and the product will be of inferior quality. The mixture was cooled to 18−20 °C between each addition. After addition of P2O5 was completed, the mixture was stirred at 18−25 °C for 10−15 min. 1,2:5,6-Di-O-isopropylidene-D-glucofuranose (260 g, 1.0 mol) was dissolved in anhydrous DMSO (1.3 L) and added over 30 min (maintaining the temperature at 18−25 °C) to the stirred solution of P2O5 in DMSO under a N2 atmosphere. The resulting solution was heated to 50−55 °C for 3 h. TLC (eluent: CH2Cl2:MeOH, 95:5) shows complete conversion of glucofuranose (Rf = 0.68) to ulose (Rf = 0.81). The reaction mixture was allowed to reach 25−30 °C and was extracted twice with methyl tert-butyl ether (MTBE 1.5 and 1 L) in a 6-L separation funnel. The combined MTBE layer (~4 L) was concentrated in vacuo (water-bath temperature set to 40 °C) to approximately 2 L and allowed to reach 25−30 °C. NaBH4 (24 g, 0.63 mol) was dissolved in water (1 L, 55.6 mol) at 0−10 °C, and the concentrated MTBE layer was added to the aqueous layer over 30 min to keep  the temperature at 0−10 °C. TLC (eluent: EtOAc/heptane, 6:4) after 30 min shows  full conversion of ulose (Rf = 0.53) to 1,2:5,6-di-O-isopropylidene-D-allofuranose (Rf = 0.39). The reaction mixture was allowed to reach 25−30 °C. CH2Cl2 (1 L) and water (500 mL) were added, and the layers were separated. The aqueous layer was extracted once more with CH2Cl2 (500 mL). The combined organic layers were concentrated in vacuo to an oil which was subsequently dissolved in MTBE (300 mL) and extracted with water (3 × 500 mL). The combined aqueous layers were extracted with CH2Cl2 (3 × 500 mL). The combined CH2Cl2 layers were dried (Na2SO4, 100 g), fifiltered, and concentrated in vacuo to provide the crude oil. Crystallization from cyclohexane (500 mL), washing of crystals with cold n-pentane, and drying hereof in vacuo afforded analytically pure 1,2:5,6-di-O-isopropylidene-D-allofuranose (191 g, 73%).
Systhesis of 1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose
Reference: Christensen, S. M.; Hansen, H. F.; Koch, T. Org. Proc. Res. Dev. 2004, 8, 777−780.
Chemical PropertiesWhite Solid
UsesProtected α-D-Allofuranose
1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Preparation Products And Raw materials
Preparation Products3-O-BENZYL-4-(HYDROXYMETHYL-1,2-O-ISOPROPYLIDENE)-ALPHA-D-ERYTHROPENTOFURANOSE-->3-O-Benzyl4-C-(methanesulfonyloxymethyl)-5-O-methanesulfonyl-1,2-O-isopropylidene-a-D-ribofuranose
1,2:5,6-DI-O-CYCLOHEXYLIDENE-3-CYANO-ALPHA-D-ALLOFURANOSE 1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Azlocillin sodium 1,2:5,6-DI-O-ISOPROPYLIDENE-ALPHA-D-RIBO-3-HEXOFURANOSE-3-ULOSE MONOHYDRATE Diacetone-D-glucose 1,2:5,6-DI-O-CYCLOHEXYLIDENE-3-O-METHYLSULFONYL-ALPHA-D-ALLOFURANOSE 3-O-BENZYL-1,2:5,6-DI-O-ISOPROPYLIDENE-ALPHA-D-ALLOFURANOSE D-(+)-ALLOSE Azlocillin ALOSETRON

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