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| | TETRAMETHYLTIN Basic information |
| | TETRAMETHYLTIN Chemical Properties |
| Melting point | −54 °C(lit.) | | Boiling point | 74-75 °C(lit.) | | density | 1.291 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.441(lit.) | | Fp | 9 °F | | storage temp. | Store below +30°C. | | form | liquid | | color | colorless | | Specific Gravity | 1.291 | | Water Solubility | Insoluble in water. Soluble in organic solvents | | Hydrolytic Sensitivity | 1: no significant reaction with aqueous systems | | BRN | 3647887 | | CAS DataBase Reference | 594-27-4(CAS DataBase Reference) | | EPA Substance Registry System | Stannane, tetramethyl- (594-27-4) |
| Hazard Codes | T+,N | | Risk Statements | 26/27/28-50/53 | | Safety Statements | 26-27-28-45-60-61 | | RIDADR | UN 3384 6.1/PG 1 | | WGK Germany | 2 | | RTECS | WH8630000 | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29310099 |
| | TETRAMETHYLTIN Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Uses | Tetramethyltin is used in many organic syntheticreactions. | | Uses | Tetramethylstannane is used in preparation of Biphenyl Pyrazines as PD-1/PD-L1 inhibitors for treating cancer. | | Definition | ChEBI: An organotin compound carrying four methyl groups. | | Health Hazard | Tetramethyltin is moderately toxic by allroutes of exposure. The symptoms includeheadache, muscle weakness, and paralysis.Exposure limits:
TLV-TWA: 0.1 mg (Sn)/m3 (skin) (ACGIH)
PEL-TWA: 0.1 mg (Sn)/m3 (skin) (OSHA). | | Fire Hazard | The ease of oxidation, however, is low in
comparison with most other metal alkyls. It
is relatively stable to air and does not ignite spontaneously as other alkyls do. Also, it
is stable in water. The compound, however,
is highly flammable, the flash point being
( －13°C) 9°F (Aldrich 1996). It explodes
violently in contact with dinitrogen tetraoxide
even, at －80°C (－112°F) (Bailar 1973).
Reaction with strong oxidizers is expected to
be vigorous to violent. | | Safety Profile | Moderately toxic by inhalation. A very dangerous fire and explosion hazard when exposed to heat, flame, or oxidizers. Powerful explosive reaction with dinitrogen tetroxide. To fight fire, use water, foam, CO2, dry chemical. When heated it emits acrid smoke and irritating fumes. See also TIN COMPOUNDS and ORGANOMETALS. | | Purification Methods | It is purified by fractionation using a Todd column (p 11) of 35-40 plates at atmospheric pressure. The purity of the fractions can be followed by IR [Edgell & Ward J Am Chem Soc 77 6486 1955]. It readily dissolves stopcock silicone greases which give bands in the 8-10a region. [Edgell & Ward J Am Chem Soc 76 1169 1954, Beilstein 4 IV 4307.] |
| | TETRAMETHYLTIN Preparation Products And Raw materials |
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