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| | KIRENOL Basic information |
| Product Name: | KIRENOL | | Synonyms: | (1R,3S,4aS,4bS,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-Dodecahydro-3-hydroxy-7-[(R)-1,2-dihydroxyethyl]-1,4a,7-trimethylphenanthrene-1-methanol;Kirenol;KIRENOL(P);Kirel;1,7-PhenanthrenediMethanol,1,2,3,4,4a,4b,5,6,7,- 9,10,10a-dodecahydro-3-hydroxy-R7- (hydroxyMethyl)-1,4a,7-triMethyl-,(R7R,1R,- 3S,4aS,4bR,7S,10aS)-;1,7-Phenanthrenedimethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-, (α7R,1R,3S,4aS,4bR,7S,10aS)-;(1R)-1-[(2S,4aR,4bS,6S,8R,8aS)-6-hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol;KirenolQ: What is
Kirenol Q: What is the CAS Number of
Kirenol Q: What is the storage condition of
Kirenol Q: What are the applications of
Kirenol | | CAS: | 52659-56-0 | | MF: | C20H34O4 | | MW: | 338.49 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products | | Mol File: | 52659-56-0.mol |  |
| | KIRENOL Chemical Properties |
| Melting point | 197.0 to 201.0 °C | | Boiling point | 516.9±35.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Ethanol (Slightly), Methanol (Slightly) | | form | Solid | | pka | 14.06±0.20(Predicted) | | color | White to Light Yellow | | CAS DataBase Reference | 52659-56-0 |
| Safety Statements | 24/25 | | RTECS | SF7352310 | | HS Code | 29399990 |
| | KIRENOL Usage And Synthesis |
| Description | Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC50 value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively. | | Uses | Kirenol is a pharmaceutical agent that induces apoptosis in human chronic myeloid leukemia cells. | | Definition | ChEBI: Kirenol is a diterpenoid. |
| | KIRENOL Preparation Products And Raw materials |
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