(R)-(-)-2-PHENYLBUTYRIC ACID

(R)-(-)-2-PHENYLBUTYRIC ACID Basic information

Product Name:	(R)-(-)-2-PHENYLBUTYRIC ACID
Synonyms:	(R)-(-)-alpha-Ethylphenylaceticacid;(R)-(-)-2-Phenylbutyricacid,98+%;(r)-(-)-à-ethylphenylacetic acid;(2R)-2-Phenylbutanoic acid;(2R)-2-Phenylbutyric acid;(αR)-α-Ethylbenzeneacetic acid;(R)-(-)-2-Phenylbutyric acid,99%;(R)-(-)-2-Phenylbutyric acid, 99% 1GR
CAS:	938-79-4
MF:	C10H12O2
MW:	164.2
EINECS:
Product Categories:	Carboxylic Acids;Chiral Building Blocks;Organic Building Blocks
Mol File:	938-79-4.mol

(R)-(-)-2-PHENYLBUTYRIC ACID Chemical Properties

alpha	[α]D20 -92～-98゜ (c=4, C6H5CH3)
Boiling point	102-104 °C/0.4 mmHg (lit.)
density	1.055 g/mL at 25 °C (lit.)
refractive index	n20/D 1.516
Fp	>230 °F
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Ethanol (Slightly), Toluene (Slightly)
form	Liquid
color	Clear colorless
optical activity	[α]20/D 93°, c = 0.9 in toluene
BRN	2327346
CAS DataBase Reference	938-79-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	23-36
WGK Germany	3
HS Code	29163900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

(R)-(-)-2-PHENYLBUTYRIC ACID Usage And Synthesis

Chemical Properties	clear colorless liquid
Uses	(R)-(-)-2-Phenylbutyric Acid, is the metabolite of Butamirate (B690025), which is a novel antitussive drug.
Purification Methods	Purify the acids by distillation at atmospheric pressure using an efficient column. The acid chlorides have b 106-107o/20mm, []D () and (+) 108o (c 2, *C6H6). [Levene et al. J Biol Chem 100 589 1933, Gold & Aubert Helv Chim Acta 41 1512 1958, ORD in heptane: Rothen & Levene J Chem Phys 7 975 1939, Beilstein 9 III 2461.]

(R)-(-)-2-PHENYLBUTYRIC ACID Preparation Products And Raw materials

Raw materials	(E)-2-Phenyl-2-butenoic acid-->2-PHENYLBUTYRIC ACID ANHYDRIDE-->Phenylacetyl chloride-->2-Phenylbutyric acid
Preparation Products	(S)-(+)-2-PHENYLBUTYRIC ACID

FMOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID [R,(-)]-3-Methyl-2-phenylbutyric acid (S)-4-AMINO-3-PHENYLBUTANOIC ACID FMOC-(S)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID (S)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE BOC-(S)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID (S)-2-Hydroxy-2-phenylbutyric acid [S,(+)]-2-Methyl-4-phenylbutyric acid ethyl ester BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID rac-(2R*)-2-Amino-2-phenylbutyric acid FMOC-(S)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID FMOC-(R)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID 2-Phenylbutyric acid ethyl ester FMOC-(S)-3-AMINO-4-(4-NITRO-PHENYL)-BUTYRIC ACID BOC-(R)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID (3R)-3-Phenylbutyric acid BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID FMOC-(S)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID

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