N-Acetyl-L-proline

N-Acetyl-L-proline Basic information
Product Name:N-Acetyl-L-proline
Synonyms:N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline;(2S)-1-acetyl-2-pyrrolidinecarboxylate;(S)-N-Acetylproline;L-N-Acetylproline;NSC 280718;N-Ac-Pro-OH;ASINEX-REAG BAS 16579166;ACETYL-L-PROLINE
CAS:68-95-1
MF:C7H11NO3
MW:157.17
EINECS:200-698-9
Product Categories:A - H;Amino Acids;chiral;Amino Acid Derivatives;Amino Acids;Modified Amino Acids;ACETYLGROUP;PYRROLE;pharmacetical;N-Acetyl-Amino acid series;amino;bc0001
Mol File:68-95-1.mol
N-Acetyl-L-proline Structure
N-Acetyl-L-proline Chemical Properties
Melting point 115-117 °C
alpha -86 º (c=1 EtOH)
Boiling point 366.2±35.0 °C(Predicted)
density 1.274±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
pka3.69±0.20(Predicted)
form Powder
color White to off-white
BRN 83200
InChIKeyGNMSLDIYJOSUSW-LURJTMIESA-N
CAS DataBase Reference68-95-1(CAS DataBase Reference)
NIST Chemistry ReferenceL-proline, 1-acetyl-(68-95-1)
Safety Information
Hazard Codes Xi
Safety Statements 24/25
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
MSDS Information
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N-Acetyl-L-proline English
ACROS English
SigmaAldrich English
ALFA English
N-Acetyl-L-proline Usage And Synthesis
Chemical Propertieswhite to off-white powder
UsesN-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.
DefinitionChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.
Biochem/physiol ActionsN-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.
N-Acetyl-L-proline Preparation Products And Raw materials
N-Acetyl-L-proline (4S)-4-Phenyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline. Dicyclohexylamine N-Acetyl-L-cysteine Acetylacetone N-ALPHA-ACETYL-L-PROLINE N-METHYLAMIDE N-ALPHA-ACETYL-D-PROLINE,N-ACETYL-D-PROLINE,ACETYL-D-PROLINE D-Proline 4β-Phenyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-proline tert-Butyl Ester,7-Methoxycoumarin-4-Acetyl-L-proline tert-Butyl Ester Acetyl chloride Fosinopril sodium (4R)-4-Cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline sodium salt L-Proline cis-4-Hydroxy-L-proline acetyl-seryl-aspartyl-(N-acetyl)-lysyl-proline (4S)-4-Cyclohexyl-1-[(4-phenylbutyl)phosphinyl]acetyl-L-proline L-PROLINE-(4-3H(N)) (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenyl-d5-butyl)phosphinyl]acetyl]-L-proline Sodium Salt

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