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| | 1,1-Dimethylhydrazine Basic information |
| | 1,1-Dimethylhydrazine Chemical Properties |
| Melting point | -57.2 °C | | Boiling point | 60-62 °C(lit.) | | density | 0.79 g/mL at 20 °C(lit.) | | vapor density | 1.94 (vs air) | | vapor pressure | 103 mm Hg ( 20 °C) | | refractive index | n20/D 1.4075(lit.) | | Fp | 34 °F | | storage temp. | 2-8°C | | solubility | Miscible with alcohol, N,N-dimethylformamide, ether, hydrocarbons (Windholz et al., 1983), and
many other polar solvents. | | pka | 8.19±0.18(Predicted) | | form | Colorless liquid | | explosive limit | 95% | | Water Solubility | miscible | | Sensitive | Hygroscopic | | Merck | 14,3247 | | BRN | 605261 | | Henry's Law Constant | 2.45(x 10-9 atm?m3/mol) at 25 °C (quoted, Mercer et al., 1990) | | Exposure limits | TLV-TWA skin 0.5 ppm (1.0 mg/m3 )
(ACGIH, MSHA, and OSHA); carcinogenicity:
Animal Sufficient Evidence (IARC), Suspected Carcinogen (ACGIH). | | CAS DataBase Reference | 57-14-7(CAS DataBase Reference) | | IARC | 2B (Vol. 4, Sup 7, 71) 1999 | | NIST Chemistry Reference | Hydrazine, 1,1-dimethyl-(57-14-7) | | EPA Substance Registry System | 1,1-Dimethylhydrazine (57-14-7) |
| | 1,1-Dimethylhydrazine Usage And Synthesis |
| Chemical Properties | 1,1-Dimethylhydrazine is a colorless, flammable, hygroscopic liquid that gradually turns
yellow on contact with air and is miscible with water. 1,1-Dimethylhydrazine is primar-
ily used as a high-energy fuel in military applications, as a rocket propellant and fuel for
thrusters, and small electrical power-generating units. 1,1-Dimethylhydrazine is also used
in the manufacture of a plant growth regulator, in chemical synthesis, in photographic
chemicals, as a stabilizer for fuel additives, and as an absorbent for acid gases. Exposure
to 1,1-dimethylhydrazine usually occurs at the workplace during use and handling of the
chemical substance.
No information is available on the carcinogenic effects of 1,1-dimethylhydrazine in humans.
Carcinogenic effects were observed in mice and rats exposed to 1,1-dimethylhydrazine
by inhalation, but the carcinogenicity could not be defi nitively attributed to
1,1-dimethylhydrazine because of the presence of contaminants in the study. The US EPA
has not classifi ed 1,1-dimethylhydrazine for potential carcinogenicity, while the IARC has
classifi ed 1,1-dimethylhydrazine as Group 2B, meaning a possible human carcinogen. | | Physical properties | Clear, colorless fuming liquid with an amine-like odor. Turns yellow on exposure to air. Odor
detection threshold concentrations ranged from 6.1 to 14 ppmv (Jacobson et al., 1955). | | Uses | 1,1-Dimethylhydrazine is used in rocket fuel. | | Uses | Base in rocket fuel formulations; intermediate
in organic synthesis | | Uses | N,N-Dimethylhydrazine is used as a reagent in the synthesis of novel substituted pyridinylbenzenesulfonamide derivatives which have herbicidal activity. N,N-Dimethylhydrazine is also used in the preparation of the antibacterial agent, (-)-Platencin. | | Definition | ChEBI: A member of the class of hydrazines that is hydrazine substituted by two methyl groups at position 1. | | General Description | A clear colorless liquid with an ammonia-like odor. Flash point 0°F. Corrosive to the skin. Less dense than water and soluble in water. Vapors are heavier than air and very toxic by inhalation, attacking the eyes and respiratory system. Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Generates toxic oxides of nitrogen when burned. Vapors may travel to a source of ignition and a flame can flashback to the source of vapors. Used as a rocket propellant and to make other chemicals. | | Air & Water Reactions | Highly flammable over a wide range of vapor concentrations. May ignite spontaneously when spread on a large surface exposed to the air. [Def. Res. and Eng., pp 299-300(1963)]. Dissolves and slowly decomposes in water. | | Reactivity Profile | 1,1-Dimethylhydrazine is a powerful reducing agent. Ignition can occur on contact with oxidizing agents such hydrogen peroxide and fuming nitric acid, [Haz. Chem. Data(1966)]. Also reacts as a base to neutralize acids in exothermic reactions. | | Health Hazard | 1,1-Dimethylhydrazine exhibits high acute toxicity as a result of exposure by all routes. Death or permanent injury may result after very short exposure to small quantities. Chronic exposure may cause pneumonia, liver damage, and kidney damage. | | Health Hazard | The vapors of this compound are irritating tothe eyes, nose, and throat. The liquid is corrosive to the skin. The toxic properties aresimilar to those of 1,1-dimethylhydrazine.Exposure to 280 ppm for 4 hours was fatalto rats. The oral LD50 value in th. | | Fire Hazard | Vapor may explode if ignited in an enclosed area. Vapors may travel to a source of ignition and flashback. Runoff to sewer may create fire or explosion hazard. When 1,1-Dimethylhydrazine decomposes, 1,1-Dimethylhydrazine gives off toxic nitrogen compound fumes. Dissolves, swells, and disintegrates many plastics. Dangerous when exposed to heat, flame, or oxidizers. Hazardous polymerization may not occur. | | Safety Profile | Confirmed carcinogen
with experimental carcinogenic,
tumorigenic, and teratogenic data. Other
experimental reproductive effects. Poison byingestion, intraperitoneal, intravenous, and
intracerebral routes. Moderately toxic by
inhalation and skin contact. Human
mutation data reported. A plant growth
control agent. Corrosive. A powerful
reducing agent. A dangerous fire hazard. It
is hypergolic with many oxidants (e.g.,
dinitrogen tetroxide, hydrogen peroxide, and
nitric acid). Dangerous when exposed to
heat, flame, or oxidizers; can react
vigorously with oxidning materials such as
air, fuming HNO3, (HNO3 + N2O4), NO. A
high-energy propellant for liquid-fueled
rockets. To fight fire, use alcohol foam,
CO2, dry chemical. When heated to
decomposition it emits highly toxic fumes of
NOx. See also HYDRAZINE. | | Carcinogenicity | 1,1-Dimethylhydrazine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. | | Environmental fate | Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and
Lewis, 1987). Ignites spontaneously in air or in contact with hydrogen peroxide, nitric acid, or
other oxidizers (Patnaik, 1992).
N-Nitrosodimethylamine was the major product of ozonation of 1,1-dimethylhydrazine in the
dark. Hydrogen peroxide, methyl hydroperoxide, and methyl diazene were also identified (HSDB,
1989). | | Purification Methods | Fractionally distil the hydrazine through a 4-ft column packed with glass helices. Precipitate it as its oxalate from diethyl ether solution. After crystallising from 95% EtOH, the salt is decomposed with aqueous saturated NaOH, and the free base is distilled, dried over BaO and redistilled [McBride & Kruse J Am Chem Soc 79 572 1957]. Distillation and storage should be under nitrogen. [Beilstein 4 IV 3322.] |
| | 1,1-Dimethylhydrazine Preparation Products And Raw materials |
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