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| | 2,4,5-Trichloropyrimidine Basic information |
| Product Name: | 2,4,5-Trichloropyrimidine | | Synonyms: | 2,4,5-TRICHLOROPYRIMIDINE;2,5,6-TRICHLOROPYRIMIDINE;2,4,5-TRICHLOROPYRIMIDINE, 97+%;2,4,5-Trichloropyrimidine, 99+%;2,4,5-Trichloropyrimidine ,98%;2,4,5-Trichloro-1,3-diazine;2,4,5-three chloropyriMidine;2,4,5-TrichL | | CAS: | 5750-76-5 | | MF: | C4HCl3N2 | | MW: | 183.42 | | EINECS: | 628-281-0 | | Product Categories: | Heterocycle-Pyrimidine series;Pyrimidine series;Halogenated;Organohalides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Heterocycles;pharmacetical;Halides;Pyrazines, Pyrimidines & Pyridazines;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Pyrimidine;bc0001 | | Mol File: | 5750-76-5.mol |  |
| | 2,4,5-Trichloropyrimidine Chemical Properties |
| Boiling point | 84°C 1mm | | density | 1.6001 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.574(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | form | clear liquid | | pka | -4.26±0.29(Predicted) | | color | Colorless to Light orange to Yellow | | Water Solubility | Not miscible or difficult to mix in water. | | BRN | 4449 | | InChI | InChI=1S/C4HCl3N2/c5-2-1-8-4(7)9-3(2)6/h1H | | InChIKey | GIKMWFAAEIACRF-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=C(Cl)C(Cl)=N1 | | CAS DataBase Reference | 5750-76-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | 3267 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29335990 |
| | 2,4,5-Trichloropyrimidine Usage And Synthesis |
| Chemical Properties | Colorless to pale yellow liquid | | Uses | 2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. Also used in the synthesis of EGFR inhibitors. |
| | 2,4,5-Trichloropyrimidine Preparation Products And Raw materials |
| Raw materials | 5-Chlorouracil-->Disulfur dichloride | | Preparation Products | 2,5-dichloro-4-(methylthio)pyrimidine-->2,5-Dichloro-N-(5-methyl-1H-pyrazol-3-yl)-4-pyrimidinamine-->2,5-dichloro-4-ethoxypyriMidine-->1-(2,5-DichloropyriMidin-4-yl)-1H-indole-->2,5-Dichloro-4-(4-methoxyphenoxy)pyrimidine-->Methyl 4-(2,5-Dichloro-4-pyrimidinyl)benzoate-->1-(2,5-Dichloropyrimidin-4-yl)-1H-benzo[d]imidazole-->BenzaMide, 2-[(2,5-dichloro-4-pyriMidinyl)aMino]--->4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]--->BenzenesulfonaMide, 2-[(2,5-dichloro-4-pyriMidinyl)aMino]-N-Methyl--->2-(2,5-dichloropyrimidin-4-ylamino)-N,N-dimethylbenzenesulfonamide-->C12H10Cl2N4O |
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