ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives Hydrocarbon halides 1-BROMO-2-BUTYNE

1-BROMO-2-BUTYNE

1-BROMO-2-BUTYNE Basic information
Product Name:1-BROMO-2-BUTYNE
Synonyms:1-BROMO-2-BUTYNE;1-BROMO-2-BUTYNE 98%;1-Bromo-2-butyne,98%;But-2-yn-1-yl bromide;1-broMo -2-Ding Que;1-BroMo-2-butyne, 96.0%(GC);Linagliptin INT4;1-Bromo-2-butyne (Linagliptin)
CAS:3355-28-0
MF:C4H5Br
MW:132.99
EINECS:608-891-3
Product Categories:Intermediates;Acetylenes;Functionalized Acetylenes;Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks
Mol File:3355-28-0.mol
1-BROMO-2-BUTYNE Structure
1-BROMO-2-BUTYNE Chemical Properties
Boiling point 40-41 °C/20 mmHg (lit.)
density 1.519 g/mL at 25 °C (lit.)
refractive index n20/D 1.508(lit.)
Fp 97 °F
storage temp. Inert atmosphere,Room Temperature
solubility Miscible with acetonitrile.
form Liquid
Specific Gravity1.519
color Clear pale yellow-greenish
BRN 605306
InChIKeyLNNXOEHOXSYWLD-UHFFFAOYSA-N
CAS DataBase Reference3355-28-0(CAS DataBase Reference)
Safety Information
Risk Statements 10
Safety Statements 16-24/25
RIDADR UN 1993 3/PG 3
WGK Germany 3
F 10-23
HazardClass 3
PackingGroup III
HS Code 29033990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
1-BROMO-2-BUTYNE Usage And Synthesis
Chemical PropertiesClear pale yellow-greenish liquid
Uses1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.
Preparation1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction.
General Description1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin.
1-BROMO-2-BUTYNE Preparation Products And Raw materials
Preparation Products1-PHTHALIMIDO-2-BUTYNE-->2-Butyn-1-amine, N-2-propyn-1-yl--->DI-BUT-2-YNYL-AMINE-->8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
bamboo flavone Lercanidipine Levetiracetam Adapalene Rivaroxaban 1-(3-BROMOPROP-1-YNYL)-3,5-DI(TRIFLUOROMETHYL)BENZENE 1-BROMO-2-BUTYNE 2-BROMO-3-HEXYNE 1,4-DIBROMO-2-BUTYNE 1-Bromo-1-butyne 1-BROMO-2-PENTYNE 3-Bromo-1-butyne 2-Methyl-4-bromo-3-butyne-2-ol 1-Bromo-3-butyne,4-BROMO-1-BUTYNE 2-Bromo-3-Butyne 2-Butyne 1-(3-BROMO-1-PROPYNYL)NAPHTHALENE 1-BROMO-2-OCTYNE
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