3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Basic information
Product Name:3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Synonyms:3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]-pyrididine-4-one (intermediate of Risperidone);3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-CHLORO-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDINO[1,2-A]PYRIMIDINE-4-ONE;3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO(1,2A)PYRIMIDINE-4-ONE;3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRLDO[1,2-A]PYRIMDIN-4-ONE;3-2(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimnidin-4-one;3-2(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]PYRIMDIN-4-ONE
CAS:63234-80-0
MF:C11H15ClN2O
MW:226.7
EINECS:613-192-1
Product Categories:Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides and Nucleosides;Nucleotides;Pharmaceuticals;Intermediates;(intermediate of Risperidone)
Mol File:63234-80-0.mol
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Structure
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties
Melting point 68.5-69.5 °C
Boiling point 337 °C
density 1.30
Fp 157 °C
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka3.58±0.70(Predicted)
color White to Off-White
InChIKeyCMWCQQUYLPYOMY-UHFFFAOYSA-N
CAS DataBase Reference63234-80-0(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
HS Code 2933.99.9701
HazardClass IRRITANT
MSDS Information
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Usage And Synthesis
Chemical PropertiesWhite Solid
Uses3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Ethyl acetate-->Dichloromethane-->PETROLEUM ETHER-->Toluene-->Phosphorus oxychloride-->Ammonium hydroxide-->Isopropyl alcohol-->Hydrogen-->Palladium hydroxide-->2-Aminopyridine-->2-Acetylbutyrolactone-->3-(2-Chloroethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one
Methylparaben 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Methyl Bensulfuron methyl 2-Chloro-5-chloromethylpyridine Parathion-methyl 4-Methylpyridine 2-Butanone Azamethiphos Kresoxim-methyl 2,6-Lutidine Thiophanate-methyl Pirimiphos-methyl Methyl acrylate Methyl acetate Methyl bromide METHYL THIOPHENE-2-CARBOXYLATE

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