EPIDERMAL GROWTH FACTOR, HUMAN

EPIDERMAL GROWTH FACTOR, HUMAN Basic information
Product Name:EPIDERMAL GROWTH FACTOR, HUMAN
Synonyms:RHEGF;REC EGF (HUMAN);REC EPIDERMAL GROWTH FACTOR (HUMAN);RECOMBINANT HUMAN EGF;LONG EGF;ASN-SER-ASP-SER-GLU-CYS-PRO-LEU-SER-HIS-ASP-GLY-TYR-CYS-LEU-HIS-ASP-GLY-VAL-CYS-MET-TYR-ILE-GLU-ALA-LEU-ASP-LYS-TYR-ALA-CYS-ASN-CYS-VAL-VAL-GLY-TYR-ILE-GLY-GLU-ARG-CYS-GLN-TYR-ARG-ASP-LEU-LYS-TRP-TRP-GLU-LEU-ARG;EGF, HUMAN;EGP
CAS:62229-50-9
MF:C257H381N73O83S7
MW:6045.66934
EINECS:263-468-7
Product Categories:BEAUTY PEPTIDES
Mol File:62229-50-9.mol
EPIDERMAL GROWTH FACTOR, HUMAN Structure
EPIDERMAL GROWTH FACTOR, HUMAN Chemical Properties
storage temp. -20°C
form powder
color white to off-white
CAS DataBase Reference62229-50-9
Safety Information
Hazard Codes B
WGK Germany 3
RTECS KB4518000
10-21
MSDS Information
ProviderLanguage
SigmaAldrich English
EPIDERMAL GROWTH FACTOR, HUMAN Usage And Synthesis
DescriptionEpidermal growth factor (EGF) is a polypeptide ligand for the EGF receptor (EGFR; ). It is synthesized as a 1,217 amino acid glycosylated transmembrane precursor protein from which mature, soluble EGF is formed by proteolysis. Mature EGF is a 53-amino acid polypeptide that contains six cysteine residues, which form three intramolecular disulfide bonds essential to the biological activity of EGF. EGF is synthesized in the brain, kidney, pancreas, small intestine, pituitary gland, and submaxillary gland and is found in various bodily fluids, including saliva, cerebrospinal fluid, blood, breast milk, and prostatic fluid. Binding of EGF to the EGFR induces receptor dimerization, autophosphorylation, and intracellular signaling with roles in cell proliferation. In patients with early Parkinson’s disease and Alzheimer’s disease with amnestic mild cognitive impairment, low plasma EGF levels are predictive of future long-term cognitive decline. Plasma levels of EGF are reduced in pregnant woman infected with T. cruzi compared with uninfected pregnant controls. Exogenous application of EGF normalizes cortical GABAergic transmission and improves rotarod performance in the R6/2 transgenic mouse model of Huntington''s disease. Probiotic administration of E. coli engineered to secrete human EGF induces epithelial barrier restoration in a mouse model of intestinal ulcers. Immunization with human EGF induces an anti-EGF antibody response and increased survival in mice with EGFR-expressing tumors. Cayman''s EGF (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 54 amino acids and has a calculated molecular mass of 6.3 kDa.
UsesEpidermal Growth Factor (EGF) from murine submaxillary gland has been used as a mitogen, triggering the cell to commence mitosis, in a variety of cell lines. In tissue cultures, EGF acts to reduce or eliminate the requirement for serum and can be used in conjunction with other media additives and hormone. The working concentration for EGF is generally 0.1-10 ng/mL.
General DescriptionEGF (epidermal growth factor) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Recombinant murine EGF is a 6kDa globular protein containing 53 amino acid residues, including 3 intramolecular disulfide-bonds.
Biochem/physiol ActionsEGF (epidermal growth factor) has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF (transforming growth factor)-α and VGF (vaccinia virus growth factor). EGF plays an important role in embryogenesis and cardiogenesis.
EPIDERMAL GROWTH FACTOR, HUMAN Preparation Products And Raw materials
Raw materialsTRIS BORATE EDTA BUFFER, 10X, DNASE, RNASE AND PROTEASE FREE, PH 8.3, FOR MOLECULAR BIOLOGY
EGFR-ⅤⅢ (3-[125I]IODOTYROSYL)EPIDERMAL GROWTH FACTOR, HUMAN ANTI-REC EPIDERMAL GROWTH FACTOR (HUMAN) Epidermal Growth Factor, human recombinant, 100 µ ANTI-EPIDERMAL GROWTH FACTOR, HUMAN Tris(2,4-pentanedionato)chroMiuM(III) DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) SALCOMINE HEPARIN BINDING EPIDERMAL GROWTH FACTOR, HUMAN 2,4-PENTANEDIONE, SILVER DERIVATIVE ANTI-EPIDERMAL GROWTH FACTOR, HUMAN, BIOTIN COBALT(II) ACETYLACETONATE Cupric acetylacetonate Epidermal Growth Factor, Human, Recomb. EGF-R (Epidemal growth factor receptor) Acid Red 94 Ferric acetylacetonate COBALT ETHYLENE DIAMINE CHLORIDE Human Egf Human Epidermal Growth Factor

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