Tebufenozide

Tebufenozide Basic information
General Description Chemical Properties Toxicity (to higher animals) Mechanism of Action Control object and using method Attention
Product Name:Tebufenozide
Synonyms:CONFIRM;3,5-dimethylbenzoic acid 1-(1,1-dimethylethyl)-2-(4-ethylbenzoyl)hydrazide;MIMIC;TEBUFENOCIDE;TEBUFENOZIDE;rh5992;TEBUFENOZIDE PESTANAL, 100 MG;3,5-DIMETHYLBENZOIC ACID-(1,1-DIMETHYLETHYL)-2-(4-ETHYLBENZOYL)HYDRAZIDE
CAS:112410-23-8
MF:C22H28N2O2
MW:352.47
EINECS:412-850-3
Product Categories:Growth regulatorsPesticides&Metabolites;Alpha sort;Insecticides;Pesticides;Q-ZAlphabetic;TA - TE;Agro-Products;Amines;Aromatics;Heterocycles
Mol File:112410-23-8.mol
Tebufenozide Structure
Tebufenozide Chemical Properties
Melting point 191°; mp 186-188° (Sundaram, 1081)
density 1.074±0.06 g/cm3(Predicted)
vapor pressure 3 x 10 -6 Pa (25 °C)
storage temp. 0-6°C
solubility Chloroform: Slightly Soluble,Methanol: Slightly Soluble
form neat
Water Solubility 0.83 mg l-1 (20 °C)
pka10.89±0.46(Predicted)
BRN 7822297
LogP4.240 (est)
CAS DataBase Reference112410-23-8(CAS DataBase Reference)
EPA Substance Registry SystemTebufenozide (112410-23-8)
Safety Information
Hazard Codes N
Risk Statements 51/53
Safety Statements 61
RIDADR UN 3077
WGK Germany 2
HazardClass 9
PackingGroup III
HS Code 29280000
Hazardous Substances Data112410-23-8(Hazardous Substances Data)
ToxicityLD50 orally in rats, mice: >5000 mg/kg; dermally in rats: >5000 mg/kg; LD50 in honey bees (96 hr, contact): >234 mg/bee; LC50 in mallard duck (8-day dietary): >5000 mg/kg; LC50 in rainbow trout (96 hr): 5.7 mg/l (Heller)
MSDS Information
ProviderLanguage
Tebufenozide English
Tebufenozide Usage And Synthesis
General DescriptionTebufenozide is an ecdysone insecticide, which causes the premature molting of insects by interfering with the normal development of insects. It has high insecticidal activity and high selectivity, being effective in treatment of all lepidopteran larvae, caterpillar, diamondback moth and beet armyworm. It has a strong ovicidal activity, being safe to non-target organisms. Tebfenozide has no irritating effect on the eyes and skin without any teratogenic, carcinogenic and mutagenic effects on higher animals, being of high safety to mammals, birds and natural enemies. It is an ideal insecticide during integrated control.
Chemical PropertiesPure white powder, melting point 191 ℃. Slightly soluble in water and organic solvents; stable to light. It is stable at 5 ° C in pH 7 aqueous solution upon light emission.
Toxicity (to higher animals)Low toxicity
Mechanism of ActionTebufenozide is a pro-skinning compound that selectively controls lepidopteran larvae by acting in close association with the descorticophilin receptor protein. During its effect, tebufenozide mimics the action of natural insect pest hormone 20-hydroxy-descorticoid, leading to its premature, deadly peeling.
Control object and using methodIt can be used to control a variety of lettuce larvae such as cabbage, apples and other crops. It is effective in the treatment of all instar larvae at drug interval of 14d.
  • Control Spodoptera exigua, Spodoptera litura, Spodoptera frugiperda, melon field borer and cabbage budworm; apply in the early larvae emergence, spray 1 500 ~ 2 000 times 20% SC.
  • Control apple leaf roller and peach moth worm, Spray 1000 ~ 2000 times 20% suspension.
  • Control corn borer and bean curl moth; spray 1000 ~ 2000 times 20% suspension.
Attention
  1. This product is toxic to silkworms, should pay attention to be away from the silkworm area.
  2. This product is generally effective against Plutella xylostella and can be mixed with avermectin.
  3. Spray uniformly; ensure that the contact of liquid with parasites.
  4. It is best to apply pesticide in the evening when controlling beet armyworm.
UsesSynthetic nonsteroidal ecdysone agonist causing premature molting; novel insect growth regulator specific to lepidopteran species. Insecticide.
UsesTebufenozide is used to control lepidopterous larvae on rice, fruit, row crops, nut crops, vegetables and vines and in forestry.
DefinitionChEBI: A carbohydrazide that is hydrazine in which the amino hydrogens have been replaced by tert-butyl, 3,5-dimethylbenzoyl and 4-ethylbenzoyl groups respectively. It is an insecticide used widely against caterpillars.
HazardLow toxicity by ingestion, inhalation, and skin contact.
Agricultural UsesInsecticide, Insect growth regulator: Tebufenozide is an insect growth regulator that interferes with molting of Lepidopteran larvae. It is used on fruitworm, fireworms, false armyworm, gypsy moth, and spanworms, and is applied pre-harvest. Registered for use in EU countries. Registered for use in the U.S.
Trade nameCONFIRM®; MIMIC®; RH-5992®
Metabolic pathwayOxidation of ethyl and methyl substituents of the phenyl rings of tebufenozide occurs in soils and plants, to give carboxylic acids, alcohols and a ketone.
DegradationTebufenozide was stable at 94 °C for 7 days, stable to light in pH 7 aqueous solution (25 °C) and stable in dark sterile water for 30 days (25 °C). The DT50 in natural pond water, in light, was 30 days (25 °C) (PM). It was stable in acidic and neutral buffer solutions. Hydrolysis was marked in alkaline conditions (DT50 203 days, pH 10, 20°C). Tebufenozide was stable in sterilised stream water in the dark but degraded in non-sterile water (DT50 181 days). The insecticide was photodegraded by sunlight (DT50 83 hours, summer 46°N). The results suggest that microbial degradation and photolysis will be the main routes of tebufenozide dissipation in natural aquatic conditions (Sundaram, 1994).
METHOPRENE Cyromazine Tebufenozide 3,5-DIMETHYLBENZOHYDRAZIDE CHEMPACIFIC 34309 1,2-DIBENZOYL-1-(T-BUTYL)HYDRAZINE Benzoyl hydrazine tert-Butyl hydrazine ISOPROPYL-(3-METHYL-BENZYL)-AMINE TEBUFENOZIDE SOLUTION 100UG/ML IN ACETONITRILE 1ML Formylhydrazine Ethylbenzene TEBUFENOZIDE SOLUTION 100UG/ML IN TOLUENE 1ML N,N'-DIBENZOYLHYDRAZINE 3,5-Dimethylbenzoic acid 4-ETHYLBENZYLHYDRAZINE N-(3-METHYLPHENYLMETHYL)TERT-BUTYLAMINE 4-ETHYLBENZENE-1-CARBOHYDRAZIDE

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