1-Naphthol

1-Naphthol Basic information
Product Name:1-Naphthol
Synonyms:1-naphthalenol;1-NAPHTHOL;1-naphtol;α-Hydroxynaphthalene;α-Maphthol;1-napthol(alpha-napthol);1-naphthol (alpha);1-Naphthol 97+ %
CAS:90-15-3
MF:C10H8O
MW:144.17
EINECS:201-969-4
Product Categories:Aromatics;Functional Materials;Chemistry;Dyestuff Intermediates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C9 to C20+;Cell Biology;Chemical Synthesis;Detection;Fluorescent Probes;Labels;N;Intermediates of Dyes and Pigments;Aromatic Compounds;Color Former & Related Compounds;Developer;Organic Building Blocks;Oxygen Compounds;Particles and Stains;Phenols;90-15-3;bc0001
Mol File:90-15-3.mol
1-Naphthol Structure
1-Naphthol Chemical Properties
Melting point 94-96 °C(lit.)
Boiling point 278-280 °C(lit.)
density 1.224
vapor density 4.5 (120 °C, vs air)
vapor pressure 1 mm Hg ( 94 °C)
refractive index 1.6224
Fp 125 °C
storage temp. Store below +30°C.
solubility Soluble in benzene, chloroform, ether and ethanol.
form Crystalline Flakes
pka9.34(at 25℃)
color white to off-white
OdorSlight phenolic odor
explosive limit5%
Water Solubility 436.7mg/L(25 ºC)
λmax324nm(MeOH)(lit.)
Sensitive Air & Light Sensitive
Merck 14,6383
BRN 1817321
Stability:Stable, but air and light sensitive - store under inert gas. Incompatible with strong bases, strong oxidizing agents.
InChIKeyKJCVRFUGPWSIIH-UHFFFAOYSA-N
LogP2.84 at 25℃
CAS DataBase Reference90-15-3(CAS DataBase Reference)
NIST Chemistry Reference1-Naphthalenol(90-15-3)
EPA Substance Registry System1-Naphthol (90-15-3)
Safety Information
Hazard Codes Xn,N
Risk Statements 21/22-37/38-41-51/53
Safety Statements 22-26-37/39-2-61
RIDADR UN 2811 6.1/PG 3
WGK Germany 1
RTECS QL2800000
8-23
Autoignition Temperature510 °C
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29071510
Hazardous Substances Data90-15-3(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 1870 mg/kg LD50 dermal Rabbit 880 mg/kg
MSDS Information
ProviderLanguage
Oxidation base 33 English
SigmaAldrich English
ACROS English
ALFA English
1-Naphthol Usage And Synthesis
Description1-Naphthol, or α-naphthol, is a fluorescent organic compound with the formula C10H7OH. It is a white solid. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on the naphthalene ring. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They are precursors to a variety of useful compounds. Naphthols (both 1 and 2 isomers) are used as biomarkers for livestock and humans exposed to polycyclic aromatic hydrocarbons.
α-naphtol, combined with epichlorhydrine and sodium hydroxide to form alpha-naphtyl glycidyl ether, caused sensitization in one of three workers in a chemical plant.
Chemical PropertiesPale grey to brown solid with an unpleasant phenol odour. Darkens in the presence of light. Evaporates with water vapour. Soluble in ethanol, ether, benzene, chloroform and alkali solutions, insoluble in water. Precipitates violet when exposed to ferric chloride.
Uses1-Naphthol is used as a precursor in the manufacturing of various azo dyes and pharmaceuticals such as nadolol. It is used as biomarkers. It is used in analytical chemistry as Molisch's reagent (1-naphthol dissolved in ethanol) for checking the presence of carbohydrates. It plays an essential role with sodium hypobromite to detect the presence of arginine in proteins, which is called as Sakaguchi test.
Preparation2-Isopropylnaphthalene can be used to synthesize 1-naphthol by oxidation via the hydroperoxide (Hock synthesis).
Historically 1-naphthol was produced via caustic fusion of naphthalene-1-sulfonic acid, but this was superseded by the I.G. Farbenindustrie process involving hydrolysis of 1-naphthylamine with aqueous 22 % sulfuric acid at 200°C under pressure in a lead-lined autoclave. To obtain a purer product, Union Carbide developed a process based on catalytic oxidation of tetralin to 1-tetralol and 1-tetralone followed by dehydrogenation. The two-stage catalytic process is claimed to give an overall yield of 72% 1-naphthol, with an overall efficiency of 97%.
DefinitionChEBI: 1-naphthol is a naphthol carrying a hydroxy group at position 1. It has a role as a genotoxin and a human xenobiotic metabolite.
Application1-Naphthol is a hydroxyl-aromatic compound. It has been used as a prooxidant to analyze its ability to induce hemolysis in a zebrafish G6PD (glucose-6-phosphate dehydrogenase) deficiency model.
Synthesis Reference(s)Synthetic Communications, 21, p. 379, 1991 DOI: 10.1080/00397919108016759
Journal of the American Chemical Society, 107, p. 493, 1985 DOI: 10.1021/ja00288a037
General Description1-Naphthol, a metabolite of carbaryl and naphthanlene. It is formed by spontaneous reaction from (1R, 2S)-Naphthalene epoxide followed to form 1, 4-Dihydroxynaphthalene.
HazardToxic by ingestion and skin absorption.
Flammability and ExplosibilityNotclassified
Contact allergens1-Naphthol can be used in dye manufacture and is classified as a hair dye. Combined with epichlorhydrin and NaOH to form alpha-naphthyl glycidyl ether, it caused sensitization in one of three workers in a chemical plant.
Safety ProfilePoison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. An experimental teratogen. Experimental reproductive effects. A severe eye and skin irritant. Mutation data reported. Ingestion of large amounts can cause nephritis, vomiting, diarrhea, circulatory collapse, anemia, convulsions, and death. Can cause kidney irritation and injury to cornea and lens of the eye. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.
SynthesisTo a 10 mL pressure vessel, aryl halide (1.00 mmol), copper (I) oxide (0.05 mol), ligand (0.05 mol), 3 M sodium hydroxide (2 mL), and organic solvent (2 mL) were added. The reaction mixture was irradiated at 160 °C for 10 min with strong stirring. The reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through a plug of celite in a fritted filter funnel and washed with ethyl acetate. The product was extracted using 30 mL of ethyl acetate for three times. The organic extract is washed three times with 10 mL water and two times with 10 mL of brine. The combined organic phases were dried over anhydrous MgSO4 and the solvent was removed under reduced pressure to afford 1-naphthol.
Purification MethodsSublime 1-naphthol, then crystallise it from aqueous MeOH (charcoal), aqueous 25% or 50% EtOH, *C6H6, cyclohexane, heptane, CCl4 or H2O. Dry it over P2O5 in vacuo. The 4-nitrobenzoate has m 143o (from EtOH). [Shizuka et al. J Am Chem Soc 107 7816 1985, Beilstein 8 H 596, 6 IV 4208.]
1-Naphthol Preparation Products And Raw materials
Raw materialsSulfuric acid-->Naphthalene-->1-Naphthylamine-->Naphthalene-2-sulfonic acid-->1,2,3,4-Tetrahydronaphthalene-->2-Ethylnitrobenzene-->Ammonium hydrogen sulfate-->1-Chloronaphthalene-->1-Naphthalenesulfonic acid-->Molybdic acid
Preparation ProductsNAPROANILIDE-->1,4-Naphthoquinone-->Eriochrome Black T-->Napropamide-->2-Ethoxynaphthalene-1-carbonyl chloride-->17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal-->ETHYL 3-(6-METHOXY-2-NAPHTHYL)-3-METHYL GLYCIDATE-->2-Nitroso-1-naphthol-->METHYL 3-(6-METHOXY-2-NAPHTHYL)-3-METHYL GLYCIDATE-->3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal-->6-methoxy-alpha-methylnaphthalen-1-acetaldehyde-->17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether-->3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal-->1-Hydroxy-2-naphthoic acid-->sodium 2-[(2-hydroxynaphthyl)azo]naphthalenesulphonate-->fluorescent whitening agent OM-->1-Ethenyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthalenol-->13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one-->N,N'-Di-2-naphthyl-p-phenylenediamine-->6'-Methoxy-2'-propiononaphthone-->2-BROMO-1-(6-METHOXY-2-NAPHTHALENYL)-1-PROPANONE-->FLAVIANIC ACID-->N-(1-Naphthyl)ethylenediamine dihydrochloride-->17-Ethynyl-18-methylestra-5(10),9(11)-dien-17-ol-3-one-->ACID RED 1-->1-NAPHTHOXYACETIC ACID-->2-[(1-Naphthyloxy)methyl]oxirane-->2-(1-Naphthalenyloxy)propanoic acid-->1-ETHOXYNAPHTHALENE-->Mordant Black 3-->5,8-Dihydronaphthol-->calcium disodium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]-4-sulphonatobenzoate]-->1-NAPHTHYL CHLOROFORMATE-->1-Nitroso-2-naphthol-->1,6-DIBROMO-2-METHOXYNAPHTHALENE-->4-Amino-1-naphthol hydrochloride-->1,6-Dibromo-2-naphthol-->O-2-Naphthyl chlorothioformate-->1-(6-hydroxy-2-naphthyl)ethan-1-one
nitrazine yellow 1-NAPHTHOXYACETIC ACID 1-Naphthol (+/-)-1,1'-BI(2-NAPHTHOL) 1-NAPHTHYL BUTYRATE 1-Naphthyl acetate 2,4-DICHLORO-1-NAPHTHOL ACID RED 4 ARSENAZO I Terbinafine hydrochloride ALPHA-NAPHTHOLBENZEIN 5,8-Dihydronaphthol 4-CHLORO-1-NAPHTHOL 2-Nitroso-1-naphthol ARSENAZO III DISODIUM SALT Phenmedipham 2-Naphthol Terbinafine Hydrochloride

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