|
| | Cabotegravir (GSK744, GSK1265744) Basic information |
| Product Name: | Cabotegravir (GSK744, GSK1265744) | | Synonyms: | GSK1265744;GSK744;(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide;Cabotegravir (GSK744, GSK1265744);Cabotegravir Free Acid;Cabotegravir;Cyclic pyranopterin;SK744, GSK1265744 | | CAS: | 1051375-10-0 | | MF: | C19H17F2N3O5 | | MW: | 405.35 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1051375-10-0.mol |  |
| | Cabotegravir (GSK744, GSK1265744) Chemical Properties |
| Boiling point | 664.0±55.0 °C(Predicted) | | density | 1.57±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming | | form | solid | | pka | 4.50±1.00(Predicted) |
| | Cabotegravir (GSK744, GSK1265744) Usage And Synthesis |
| Uses | Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. | | Definition | ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-). | | Biological Activity | Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2. | | Mechanism of action | Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself. | | target | HIV integrase |
| | Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials |
|
