PIPERAZINE DIHYDROCHLORIDE

PIPERAZINE DIHYDROCHLORIDE Basic information
Product Name:PIPERAZINE DIHYDROCHLORIDE
Synonyms:diethylenediaminedihydrochloride;dihydrochloridesaltofdiethylenediamine;dihydropipwormer;dowzenedhc;piperazinehydrochloride;piperazinewormerpremix;PIPERAZINE DIHYDROCHLORIDE;PIPERAZINE HYDROCHLORIDE HYDRATE
CAS:142-64-3
MF:C4H12Cl2N2
MW:159.06
EINECS:205-551-2
Product Categories:
Mol File:142-64-3.mol
PIPERAZINE DIHYDROCHLORIDE Structure
PIPERAZINE DIHYDROCHLORIDE Chemical Properties
Melting point 320°C(dec.)(lit.)
Boiling point 262.01°C (rough estimate)
density 1.3011 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Water
form White crystalline solid
color White to Off-White
InChIInChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H
InChIKeyCVVIJWRCGSYCMB-UHFFFAOYSA-N
SMILESC1NCCNC1.Cl.Cl
LogP-1.171 (est)
CAS DataBase Reference142-64-3(CAS DataBase Reference)
EPA Substance Registry SystemPiperazine dihydrochloride (142-64-3)
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-42/43
Safety Statements 22-26-36/37
RTECS TL4025000
3-10
HS Code 2933599550
Hazardous Substances Data142-64-3(Hazardous Substances Data)
Toxicitymouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967.
MSDS Information
ProviderLanguage
ALFA English
PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis
UsesIt is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses.
UsesIn the manufacture of fibers, pharmarceuticals, and insecticides.
UsesPiperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.
General DescriptionWhite to cream-colored needles or powder. Mp: 318-20°C (with decomposition).
Reactivity ProfilePIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.
Safety ProfileModerately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.
Potential ExposureAgricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.
CarcinogenicityPiperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.
Purification MethodsCrystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]
IncompatibilitiesAqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
TRIFORINE 1-BUTYLPIPERAZINE DIHYDROCHLORIDE 1-(4-Chlorophenyl)piperazine dihydrochloride Trifluoperazine dihydrochloride 2-(1-Piperazinyl)pyrimidine 1-(4-Methoxyphenyl)piperazine 1-(4-Fluorophenyl)piperazine Hydroxyzine dihydrochloride 1-propylpiperazine dihydrochloride 1-(3-Chlorophenyl)piperazine dihydrochloride 97% 1-(m-Methoxyphenyl)-piperazine dihydrochloride H-7 DIHYDROCHLORIDE 4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE 2-(4-SULFAMYLPHENYL)-6-(6-[4-METHYLPIPERAZINO]-2-BENZIMIDAZOLYL)BENZIMIDAZOLE TRIHYDROCHLORIDE 1-(3,4-Dichlorophenyl)piperazine Pirenzepine PIPERAZINE-2-CARBOXYLIC ACID Hoechst 33342

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