Erdosteine

Erdosteine Basic information
Product Name:Erdosteine
Synonyms:2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)aMino]ethyl]thio]acetic Acid;Dithiosteine;Aceticacid, 2-[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)aMino]ethyl]thio]-;Erdostiene;2-[[2-oxo-2-[(2-oxo-3-thiolanyl)amino]ethyl]thio]acetic acid;2-[2-OXO-2-(2-OXO-TETRAHYDROTHIOPHEN-3-YLAMINO)ETHYLTHIO]ACETIC ACID;[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid;ERDOSTEINE BP98
CAS:84611-23-4
MF:C8H11NO4S2
MW:249.31
EINECS:642-172-5
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;SECRESOLV
Mol File:84611-23-4.mol
Erdosteine Structure
Erdosteine Chemical Properties
Melting point 156-160°C
Boiling point 590.4±50.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka3.71(at 25℃)
color White to Off-White
λmax236nm(H2O)(lit.)
Merck 14,3647
InChIKeyQGFORSXNKQLDNO-UHFFFAOYSA-N
CAS DataBase Reference84611-23-4(CAS DataBase Reference)
Safety Information
RTECS AJ1476200
HS Code 2934.99.9001
ToxicityLD50 in mice and rats (g/kg): >10 orally; >3.5 i.v. (Gonella)
MSDS Information
Erdosteine Usage And Synthesis
DescriptionErdosteine is a new expectorant introduced in France for the treatment of chronic bronchitis. Erdosteine possesses mucomodulator, mucolytic, mucokinetic and free radical scavenging properties. Its therapeutic efficacy has been demonstrated in patients affected by congestion and viscous mucus in higher and lower respiratory tracts as in acute and chronic bronchitis, sinusitis, otitis, tracheopharyngitis and coryza. Erdosteine acts through its active metabolites containing free sulfhydryl groups which are able to depolymerize the mucopolysaccharides of the excreatum by breaking the disulfide linkages (thereby lowing its viscosity). The prodrug approach provides unique characteristics to erdosteine by offering stable therapeutic efficacy and prevention of the gastric mucus from lythic phenomena. The agent was also reported to have local antiinflammatory and antielastase properties and enhances penetration of antibiotics into bronchial mucus.
DescriptionErdosteine is a mucolytic agent and an antioxidant. It inhibits LPS-induced IκB kinase (IKK) activity, NF-κB-mediated transcription, and production of IL-6 and IL-1β in RAW 264.7 cells. Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin . It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Item Nos. 90260 | 24659). Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Chemical PropertiesOff-White Solid
OriginatorRefarmed (Switzerland)
UsesA mucolytic, developed for the treatment of chronic obstructive bronchitis.
UsesErdosteine is a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.
DefinitionChEBI: Erdosteine is a N-acyl-amino acid.
Brand nameEdirel; Vectrine
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