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| | Tiapride Basic information |
| Product Name: | Tiapride | | Synonyms: | TIAPRIDE;Tiapride hcl;N-[2-Diethylamino ethyl]-5-[methylsufonyl]-o-anisamide;Cyclovirobune D;N-(2-Diethylaminoethyl)-2-methoxy-5-methylsulfonylbenzamide;N-[2-(Ethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)benzamide;N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-2-methoxybenzamide;N-[2-(Diethylamino)ethyl]-5-mesyl-2-methoxybenzamide | | CAS: | 51012-32-9 | | MF: | C15H24N2O4S | | MW: | 328.43 | | EINECS: | 256-907-9 | | Product Categories: | Dopamine receptor;NATURETIN;Active Pharmaceutical Ingredients | | Mol File: | 51012-32-9.mol |  |
| | Tiapride Chemical Properties |
| Melting point | 123-125° | | vapor pressure | 0Pa at 25℃ | | storage temp. | 2-8°C | | pka | 9.14[at 20 ℃] | | Water Solubility | 349mg/L at 25℃ | | LogP | 0.9 | | CAS DataBase Reference | 51012-32-9(CAS DataBase Reference) |
| WGK Germany | 2 | | RTECS | CV4203800 |
| | Tiapride Usage And Synthesis |
| Originator | Tiapridal,Delagrange,France,1977 | | Uses | diuretic, antihypertensive | | Uses | Tiapride hydrochloride is a D2DR and D3DR inhibitor; Anti-psychotic agent and alternative treatment for Tourette’s syndrome. | | Definition | ChEBI: N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide is a member of benzamides. | | Manufacturing Process | 5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of
triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml
balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6
hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made
alkaline with sodium hydroxide. The precipitate formed was filtered, washed
and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy-
5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced. | | Brand name | Tiapride Hydrochloride is JAN. | | Therapeutic Function | Antiemetic |
| | Tiapride Preparation Products And Raw materials |
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