ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Arginine derivatives N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Basic information
Product Name:N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
Synonyms:N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE;Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL;Z-ARG-ARG-AMC 2HCL;Z-ARG-ARG-AMC HYDROCHLORIDE SALT;Z-ARG-ARG-MCA HYDROCHLORIDE;Z-ARG-ARG-MCA(HYDROCHLORIDE FORM);Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL;Z-RR-AMC, 2HCL
CAS:136132-67-7
MF:C30H40ClN9O6
MW:658.15
EINECS:
Product Categories:Substrates
Mol File:136132-67-7.mol
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Structure
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties
storage temp. -20°C
form aqueous solution
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Usage And Synthesis
UsesZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a cathepsin B substrate in zymography analysis of protease in feces extract.
  • in cathepsin B activity assay.
  • as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

General DescriptionHuman cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.
Biochem/physiol ActionsCathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials
Z-ARG-AMC HCL Perindopril L-Arginine NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE N-ALPHA-CBZ-ARG-ARG-PRO-PHE-HIS-STA-ILE-HIS-N-EPSILON-BOC-LYS METHYL ESTER CATHEPSIN B SUBSTRATE I, COLORIMETRIC Z-Arg-AMC N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-ALA-ARG-AMC HCL BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE BENZYL N-(4-AMINOBUTYL)CARBAMATE HYDROCHLORIDE H-ORN-AMC 2 HCL L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-GLY-GLY-AMC HCL 2-(METHYLAMINO)-N-(4-METHYLPHENYL)ACETAMIDE HYDROCHLORIDE H-ARG-ALA-NH2 2 HCL L(+)-Arginine L-ARGININE 7-AMIDO-4-METHYLCOUMARIN DIHYDROCHLORIDE
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