4-Biphenylacetic acid

4-Biphenylacetic acid Basic information

Product Name:	4-Biphenylacetic acid
Synonyms:	4-BIPHENYLACETICABID;Biphenyl-4-acetic acid 97%;4-Biphenylacetic acid/Felbinac;4 -BIPHENYLACETIC ACID 99% BP GRADE;4-BIPHENYL ACETIC ACID 98.5%;4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL;4-Biphenylacetic acid ,99%;L-141
CAS:	5728-52-9
MF:	C14H12O2
MW:	212.24
EINECS:	227-233-2
Product Categories:	Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;C13 to C42+;Carbonyl Compounds;Carboxylic Acids;Biphenyl & Diphenyl ether;Organic acids;Biphenyl derivatives;TRAXAM
Mol File:	5728-52-9.mol

4-Biphenylacetic acid Chemical Properties

Melting point	159-160 °C (lit.)
Boiling point	312.08°C (rough estimate)
density	1.1035 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	DMSO: soluble50mg/mL, clear, colorless to yellow
pka	4.29±0.10(Predicted)
form	Powder
color	Beige
Water Solubility	39.27mg/L(25 ºC)
Merck	14,3316
BRN	1211592
InChIKey	QRZAKQDHEVVFRX-UHFFFAOYSA-N
CAS DataBase Reference	5728-52-9(CAS DataBase Reference)

Safety Information

Hazard Codes	T,Xn
Risk Statements	23/25-36/37/38-25-36/37/38/63-20/21/22
Safety Statements	26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DU8229050
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29163900
Toxicity	LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)

MSDS Information

Provider	Language
4-Biphenylacetic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Biphenylacetic acid Usage And Synthesis

Description	Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.
Chemical Properties	Off-white powder
Originator	Lederle (USA)
Uses	Anti-inflammatory, analgesic drug.
Uses	4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.
Definition	ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.
Brand name	Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).
General Description	4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.
Safety Profile	Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

4-Biphenylacetic acid Preparation Products And Raw materials

Raw materials

Phenyltrimethoxysilane-->[1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER-->1-Morpholin-4-yl-2-(4-phenylphenyl)ethanethione-->carbon monoxide-->2-([1,1'-biphenyl]-4-ylmethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->4-Bromophenylacetic acid-->4-Biphenylacetonitrile-->Biphenyl-->BIPHENYL-3-CARBOXYLIC ACID ETHYL ESTER-->CARBON DIOXIDE-->4-Chlorophenylacetic acid-->4-(Chloromethyl)biphenyl-->1,1'-Biphenyl, 4-(3-chloropropyl)-

2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 4'-Chloro-5-methoxy-4-biphenylacetic acid Methyl Flurbiprofen 2',4'-difluorobiphenyl-4-acetic acid Cyclohexanol, 4-amino-1-phenyl-, alpha-ethyl-4-biphenylacetate, (Z)- 4-BIPHENYL-4'-FLUORO-ACETIC ACID Diethyl(2-hydroxyethyl)methylammonium iodide, 4-biphenylylacetate SALOR-INT L127922-1EA Xenyhexenic felbinacethyl 4'-Chloro-6-methoxy-4-biphenylacetic acid FLURBIPROFEN, [3H(G)] alpha-Methyl-4-biphenylacetic acid (S)-Flurbiprofen (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID AKOS BAR-2301 FLURBIPROFEN AXETIL Cyclohexanol, 4-amino-1-phenyl-, alpha-ethyl-4-biphenylacetate, (E)-

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