(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Basic information
Product Name:(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
Synonyms:(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER;(5-BROMOPYRAZINYL)CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER;tert-Butyl (5-bromopyrazin-2-yl);N-Boc-2-Amino-5-bromopyrazine;2-Amino-5-bromopyrazine, 2-BOC;CarbaMicacid,(5-broMopyrazinyl)-,1,1-diMethylethylester;2-Amino-5-bromopyrazine, 2-BOC protected;tert-Butyl (5-bromopyrazin-2-yl)carbamate, 2-Bromo-5-[(tert-butoxycarbonyl)amino]-1,4-diazine
CAS:914349-79-4
MF:C9H12BrN3O2
MW:274.11
EINECS:
Product Categories:
Mol File:914349-79-4.mol
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Structure
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties
Boiling point 295.2±40.0 °C(Predicted)
density 1.513±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka10.75±0.70(Predicted)
Safety Information
Hazard Codes Xn
Risk Statements 22
HS Code 2933998090
MSDS Information
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Usage And Synthesis
Uses(5-BROMOPYRAZIN-2-YL) CARBAMIC ACID TERT-BUTYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
SynthesisSynthesis_914349-79-4
At 0 ??, to 5-bromopyrazine-2-amine (5736.8mg, 32.97mmol) in CH2Cl2 (80mL) solution was added 4-DMAP (403.2mg, 3.30mmol); then at 0 ?? drop two A solution of di-tert-butyl carbonate (11.4ml, 3.30mmol) in CH2Cl2; the mixture was stirred at room temperature; after the completion of the reaction was monitored by TLC, the solution was washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo; the crude product was chromatographed on a silica gel column Method, purified with ethyl acetate/petroleum ether (1/2) to obtain a white solid product (7250.4 mg, yield 80.2%).
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER 2-Amino-5-bromopyrazine 5-BROMO-2-(METHYLAMINO)PYRAZINE

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