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| Product Name: | 5-Chloro-2-nitroaniline | | Synonyms: | TIMTEC-BB SBB003828;2-AMINO-4-CHLORO-NITROBENZENE;5-CHLORO-2-NITROANILINE;5-chloro-2-nitro-benzenamin;Benzenamine, 5-chloro-2-nitro-;2-NITRO-5-CHLOROANILINE;2-Amino-4-chloro-1-nitrobenzene;5-Chloro-2-nitrophenylamine | | CAS: | 1635-61-6 | | MF: | C6H5ClN2O2 | | MW: | 172.57 | | EINECS: | 216-661-5 | | Product Categories: | Pyrimidines;API intermediates | | Mol File: | 1635-61-6.mol |  |
| | 5-Chloro-2-nitroaniline Chemical Properties |
| Melting point | 125-129 °C (dec.)(lit.) | | Boiling point | 200°C (rough estimate) | | density | 1.5610 (rough estimate) | | refractive index | 1.5870 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble in Chloroform, Methanol | | pka | -1.46±0.25(Predicted) | | form | Liquid | | color | Clear colorless to light yellow | | BRN | 2210201 | | InChIKey | ZCWXYZBQDNFULS-UHFFFAOYSA-N | | CAS DataBase Reference | 1635-61-6(CAS DataBase Reference) |
| | 5-Chloro-2-nitroaniline Usage And Synthesis |
| Description | 2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It has been applied in the upgraded product of veterinary drug albendazole-fenbendazole, and has a broad market prospect. | | Preparation | Add 2.46mol of 2,4-dichloronitrobenzene, 7.72mol of toluene to a 3L autoclave, seal the autoclave, replace the air with nitrogen, then pass in 14.1mol of liquid ammonia, increase the temperature to 160℃, continue the reaction for 8h, and then lower the temperature to 40℃, drain the excess ammonia gas, open the kettle, add the obtained solid-liquid mixture to 800mL of water, continue to cool to 10℃, filter, add the resulting filter cake to the water, continue beating and filtering, the obtained solid is crystallized with methanol to obtain 388g , yield 91.2%, the purity of the liquid phase external standard is 99.5%. | | Chemical Properties | yellow to orange powder | | Uses | 5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates. | | Uses | 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity. | | Application | 5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.
The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. | | General Description | The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. |
| | 5-Chloro-2-nitroaniline Preparation Products And Raw materials |
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