Etymemazine

Etymemazine Basic information
Product Name:Etymemazine
Synonyms:Etymemazine;2-Ethyl-N,N,β-trimethyl-10H-phenothiazine-10-propan-1-amine;Diquel;Ethotrimeprazine;Ethylisobutrazine;RP-6484;Etymemazine [inn];Unii-861J4K81C7
CAS:523-54-6
MF:C20H26N2S
MW:326.5
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:523-54-6.mol
Etymemazine Structure
Etymemazine Chemical Properties
Boiling point 457.6±45.0 °C(Predicted)
density 1.085±0.06 g/cm3(Predicted)
pka9.34±0.28(Predicted)
Safety Information
MSDS Information
Etymemazine Usage And Synthesis
OriginatorNuital,Vaillant-Defresne
UsesA derivative of Phenothiazine, an antibacterial compound.
DefinitionChEBI: Etymemazine is a member of phenothiazines.
Manufacturing Process2.33 g 95% sodium amide were added to a boiling solution of 11.35 g 2- ethyl-10H-phenothiazine (BP: 135°-136°C) in 150 ml dry xylene by stirring at reflux for 1.5 hours. The solution of 7.72 g of 1-dimethylamino-2-methyl-3- chloropropane in 90 ml of dry xylene was poured in the above solution at the same temperature for 45 minutes. The mixture was heated at reflux else 18 hours. On cooling it was stirred with the mixture of 70 ml 1 N methanesulfonic acid and 40 ml water whereupon a xylene layer was removed. The water layer was extracted with 200 ml ether and basified with 10 ml NaOH (d=1.33), again extracted with ether and dried over potassium carbonate. The ether was distilled off, a residue was distilled to give 10-(3- dimethylamino-2-methylpropyl)-2-ethylphenothiazine; BP: 162°-182°C/0.45 mm.
The prepared base was in 60 ml acetone dissolved and 24.5 ml 1.7 N HCl was added and a precipitate of ethyl-2-(dimethylamino-3-methyl-2-propyl)-10- phenothiazine chlorohydrate dropped out. It was filtered off, washed with acetone and ether and dried. MP: 160°-163°C.
Therapeutic FunctionNeuroleptic, Antihistaminic, Hypnotic
Polyisobutylene Etymemazine Trimeprazine

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