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4-Amidinophenylmethanesulfonyl fluoride hydrochloride

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Basic information
Product Name:4-Amidinophenylmethanesulfonyl fluoride hydrochloride
Synonyms:APMSF HCL;APMSF HYDROCHLORIDE;4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORI;P-APMSF;P-APMSF, HYDROCHLORIDE;(P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE;P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL;P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE
CAS:74938-88-8
MF:C8H10ClFN2O2S
MW:252.69
EINECS:
Product Categories:inhibitor
Mol File:74938-88-8.mol
4-Amidinophenylmethanesulfonyl fluoride hydrochloride Structure
4-Amidinophenylmethanesulfonyl fluoride hydrochloride Chemical Properties
Melting point ~205 °C (dec.)
storage temp. -20°C
solubility H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.
form White solid
BRN 9083148
InChIKeyKHLLRHIUKOJXLL-UHFFFAOYSA-N
CAS DataBase Reference74938-88-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
F 10-21
HS Code 29252900
MSDS Information
ProviderLanguage
SigmaAldrich English
4-Amidinophenylmethanesulfonyl fluoride hydrochloride Usage And Synthesis
Descriptionp-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.
Biochem/physiol ActionsIrreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.
4-Amidinophenylmethanesulfonyl fluoride hydrochloride Preparation Products And Raw materials
1 VIAL PROTEASE-INHIBITOR-MIX G (31,2 MG) 1 VIAL PROTEASE-INHIBITOR-MIX FY 4-Amidinophenylmethanesulfonyl fluoride hydrochloride Sulfosulfuron (4-AMIDINOPHENYL)-METHANESULFONYL FLUORIDE HYDROCHLORIDE MONOHYDRATE (4-amidinophenyl)methanesulfonyl fluoride 4-Methylbenzene-1-carboximidamide hydrochloride METHANESULFONYL FLUORIDE Topotecan hydrochloride 4-METHYL-BENZAMIDINE sodium fluoride Benzamidine hydrochloride TITANIUM(III) FLUORIDE 4-METHYLBENZYL MERCAPTAN FLUORIDE STANDARD Chlorosulfonyl isocyanate 1,5-Diphenylcarbazide Phenylmethylsulfonyl fluoride
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