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| | kaurenoic acid Basic information |
| Product Name: | kaurenoic acid | | Synonyms: | kaurenoic acid;(-)-Kaur-16-en-18-oic acid;Cunabic acid;Kaurane-16-ene-18-oic acid;ent-Kaur-16(17)-en-19-oic acid;ent-Kaur-16-en-19-oic acid;NSC 339145;Kaur-16-en-18-oic acid,(4a)- | | CAS: | 6730-83-2 | | MF: | C20H30O2 | | MW: | 302.45 | | EINECS: | | | Product Categories: | | | Mol File: | 6730-83-2.mol |  |
| | kaurenoic acid Chemical Properties |
| Melting point | 171-172 °C | | Boiling point | 426.6±34.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 10 mg/ml | | form | A solid | | pka | 4.70±0.40(Predicted) |
| | kaurenoic acid Usage And Synthesis |
| Description | Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg. | | Uses | ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma. | | Definition | ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity. |
| | kaurenoic acid Preparation Products And Raw materials |
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