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| | 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Basic information |
| Product Name: | 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide | | Synonyms: | 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide;NSC 405020;3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE;3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020;NSC 405020 3,4-Dichloro-N-(1-methylbutyl)-benzamide;NSC 405020, >=98%;NSC 405020, 7497-07-6;NSC 405020;NSC-405020 | | CAS: | 7497-07-6 | | MF: | C12H15Cl2NO | | MW: | 260.16 | | EINECS: | 804-136-9 | | Product Categories: | Inhibitors | | Mol File: | 7497-07-6.mol |  |
| | 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Chemical Properties |
| Boiling point | 353.7±32.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). | | form | powder | | pka | 13.38±0.46(Predicted) | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26-24/25 | | RIDADR | 3077 | | WGK Germany | 3 | | HS Code | 29242990 |
| | 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Usage And Synthesis |
| Description | NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3 | | Uses | NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP. | | storage | Store at RT | | References | 1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339
2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167
3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945 |
| | 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Preparation Products And Raw materials |
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