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| | 2-Bromopyrimidine Basic information |
| Product Name: | 2-Bromopyrimidine | | Synonyms: | 2-bromo-pyrimidin;PYRIMIDINE, 2-BROMO-;Pyrimidine, 2-bromo- (7CI,8CI,9CI);2-Bromopyrimidine,98+%;2-Bromopyrimide;2-BROMOPYRIMIDINE;2-BroMpyriMidine;2-Bromopyrimidine,97+% | | CAS: | 4595-60-2 | | MF: | C4H3BrN2 | | MW: | 158.98 | | EINECS: | 224-993-7 | | Product Categories: | Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series;HALIDE;Pyrimidine;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyrazines, Pyrimidines & Pyridazines;bc0001 | | Mol File: | 4595-60-2.mol |  |
| | 2-Bromopyrimidine Chemical Properties |
| Melting point | 55-57 °C (lit.) | | Boiling point | 62-64°C (1.5 mmHg) | | density | 1.6448 (rough estimate) | | refractive index | 1.5260 (estimate) | | Fp | 62-64°C/1.5mm | | storage temp. | -20°C | | solubility | DMSO (Sparingly), Methanol (Slightly) | | pka | -1.59±0.13(Predicted) | | form | Crystalline Powder | | color | Off-white | | Water Solubility | Miscible with water. | | BRN | 605945 | | CAS DataBase Reference | 4595-60-2(CAS DataBase Reference) | | NIST Chemistry Reference | Pyrimidine, 2-bromo-(4595-60-2) | | EPA Substance Registry System | Pyrimidine, 2-bromo- (4595-60-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | Yes | | HazardClass | IRRITANT | | HS Code | 29335990 |
| | 2-Bromopyrimidine Usage And Synthesis |
| Chemical Properties | Off-white crystalline powder | | Uses | 2-Bromopyrimidine is used in the preparation of 2,7-bis(2-pyrimidyl)-9,9-dihexylfluorene by cross-coupling with 9,9-dihexylfluorene-2,7-diboronic acid. It undergoes microwave-assisted aminocarbonylation at C-2 with palladium and molybdenum hexacarbonyl. | | Preparation | The recent synthesis of 2-bromopyrimidine by diazotization of 2-aminopyrimidine in hydrobromic acid has furnished a convenient starting material for other 2-substituted pyrimidines. | | General Description | 2-Bromopyrimidine undergoes microwave-assisited aminocarbonylation at C-2 with palladium and Mo(CO)6. |
| | 2-Bromopyrimidine Preparation Products And Raw materials |
| Raw materials | 2-Chloropyrimidine-->2-Aminopyrimidine | | Preparation Products | 2-Methylpyrimidine-->2,2'-BIPYRIMIDINE-->PYRIMIDIN-2-YLBORONIC ACID-->2,4-DIBROMOPYRIMIDINE-->3-PyriMidin-2-yl-1H-indole, 98+% C12H9N3, MW: 195.23-->Pyrimidine, 2,2-(1,4-phenylene)bis- (9CI)-->Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)-->DiMethyl 2-(2-PyriMidyl)Malonate-->Pyrimidine, 2-ethenyl- (9CI)-->3-fluoro-2-(pyrimidin-2-yl)benzonitrile |
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