2-Aminoacetophenone hydrochloride

2-Aminoacetophenone hydrochloride Basic information

Product Name:	2-Aminoacetophenone hydrochloride
Synonyms:	ω-aminoacetophenone hydrochloride;w-Aminoacetophenone hydrochloride;aminomethylphenylketone hydrochloride;2-AMinoacetophenone hydrochloride, 96% 1GR;OMEGA-AMINOACETOPHENONE HYDROCHLORIDE (CA. 4% NACL);2-AMINOACETOPHENONE HYDROCHLORIDE 99%;O-aminoacetophenone HCl ,1-(o-aminophenyl)ethanone;ω-Aminoacetophenone hydrochloride, Phenacylamine hydrochloride
CAS:	5468-37-1
MF:	C8H10ClNO
MW:	171.62
EINECS:	226-787-2
Product Categories:	Ketones;Organic Building Blocks;Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis
Mol File:	5468-37-1.mol

2-Aminoacetophenone hydrochloride Chemical Properties

Melting point	194 °C (dec.)(lit.)
storage temp.	Refrigerator (+4°C)
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Crystals
color	Slightly yellow to beige
BRN	3563173
Stability:	Hygroscopic
InChI	InChI=1S/C8H9NO.ClH/c9-6-8(10)7-4-2-1-3-5-7;/h1-5H,6,9H2;1H
InChIKey	CVXGFPPAIUELDV-UHFFFAOYSA-N
SMILES	C(C1=CC=CC=C1)(=O)CN.[H]Cl
CAS DataBase Reference	5468-37-1(CAS DataBase Reference)
EPA Substance Registry System	Ethanone, 2-amino-1-phenyl-, hydrochloride (5468-37-1)

Safety Information

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

2-Aminoacetophenone hydrochloride Usage And Synthesis

Chemical Properties	Off-white crystalline
Uses	Mixed Salt of α-Aminoacetophenone, used in the preparation og pseudopeptidic inhibitors of human sirtuins1-3. This action effectually displays antiproliferative protperties in cancer cells. Also used in the preparation of dual δ/μopiod receptor agonists.
Purification Methods	Crystallise the salt from Me2CO /EtOH, EtOH/ Et2O, 2-propanol or 2-propanol and a little HCl (slowly after a fe

2-Aminoacetophenone hydrochloride Preparation Products And Raw materials

Raw materials	Ethanone, 2-azido-1-phenyl--->Formamide, N-formyl-N-(2-oxo-2-phenylethyl)--->DL-B-HYDROXYPHENETHYLAMINE HYDROCHLORIDE-->BENZOYLNITROMETHANE-->Glycine, N,N-diformyl-, ethyl ester-->2-Bromoacetophenone-->2-Chloroacetophenone
Preparation Products	4-PHENYLIMIDAZOLE-->(S)-1-(5-PHENYL-1H-IMIDAZOL-2-YL)ETHANAMINE-->(S)-(-)-2-Phenylglycinol-->2-AMINO-1-PHENYLETHANOL-->1-Amino-2-phenylbutan-2-ol-->2-(5-PHENYLOXAZOL-2-YL)PHENOL-->4-Chloro-2,5-diphenyloxazole

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