ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives Hydrocarbon nitrification 2-Nitrophenylacetonitrile

2-Nitrophenylacetonitrile

2-Nitrophenylacetonitrile Basic information
Product Name:2-Nitrophenylacetonitrile
Synonyms:(o-nitrophenyl)-acetonitril;2-nitro-benzeneacetonitril;2-nitrobenzeneacetonitrile;2-nitrobenzylnitrile;2-nitro-2-phenylacetonitrile;o-nitrobenzacetonitrile;O-NITROBENZYL CYANIDE;2-Nitrophenylacetonitrile 98%
CAS:610-66-2
MF:C8H6N2O2
MW:162.15
EINECS:210-231-0
Product Categories:Building Blocks;C8 to C9;benzene derivative;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Aromatic Nitriles;Aromatics;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
Mol File:610-66-2.mol
2-Nitrophenylacetonitrile Structure
2-Nitrophenylacetonitrile Chemical Properties
Melting point 82-85 °C(lit.)
Boiling point 178°C
density 1.3264 (rough estimate)
refractive index 1.5770 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
form Powder
color Light brown to brownish-gray
Water Solubility <0.01 g/100 mL at 20 ºC
BRN 1869400
Exposure limitsNIOSH: IDLH 25 mg/m3
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference610-66-2(CAS DataBase Reference)
EPA Substance Registry Systemo-Nitrophenylacetonitrile (610-66-2)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36-24/25
RIDADR 3439
WGK Germany 3
RTECS AM1248000
Hazard Note Irritant
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29269090
MSDS Information
ProviderLanguage
o-Nitrobenzyl cyanide English
ACROS English
SigmaAldrich English
ALFA English
2-Nitrophenylacetonitrile Usage And Synthesis
Chemical PropertiesYellow Solid
Uses2-Nitrophenylacetonitrile was used in synthesis of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones. It was used in the synthesis of strychnine.
Synthesis Reference(s)Synthesis, p. 514, 1987 DOI: 10.1055/s-1987-27989
General DescriptionLight brown solid.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileNitriles, such as 2-Nitrophenylacetonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
Fire HazardFlash point data for 2-Nitrophenylacetonitrile are not available. 2-Nitrophenylacetonitrile is probably combustible.
2-Nitrophenylacetonitrile Preparation Products And Raw materials
Preparation Products2-(2-Chlorophenyl)acetonitrile-->2-Aminobenzyl cyanide-->2-(2-NITROPHENYL)ETHANAMINE-->1H-INDAZOLE-3-CARBONITRILE-->1-(HYDROXYIMINO)-2-(2-NITROPHENYL)ETHYLAMINE
2-Nitrobenzaldehyde HYDROXY(2-NITROPHENYL)ACETONITRILE 5-Chloro-2-nitrophenylacetonitrile 4-(Trifluoromethyl)-2-nitrophenylacetonitrile Diphenylacetonitrile 2-Nitrophenol Sodium 3-nitrobenzenesulphonate 2-NITRO-4-METHYLSULFONYLTOLUENE 2-Nitrophenylacetonitrile 4-Methylbenzyl cyanide 5-FLUORO-2-NITROPHENYLACETONITRILE HYDROGEN CYANIDE Nitrobenzene sodium cyanide 3-Nitrochlorobenzene Cyanide (4,5-DIMETHOXY-2-NITRO-PHENYL)-ACETONITRILE POTASSIUM CYANIDE
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