5-Chloro-8-hydroxyquinoline

5-Chloro-8-hydroxyquinoline Basic information

Product Name:	5-Chloro-8-hydroxyquinoline
Synonyms:	5-Chloro-8-hydroxyquinoline, 95% 100GR;5-CHLORO-8-QUINOLINOL 99+%;5-CHLORO-8-HYDROXYQUINOLINE 95%;5-Chloro-8-hydroxyquinoline,95%;Clioquinol EP IMpurity A (Cloxyquin);Chloro-8-quinoli;5-Chloro-8-quinolinol, >=98%;5-CHLORO-8-HYDROXYQUINOLINE
CAS:	130-16-5
MF:	C9H6ClNO
MW:	179.6
EINECS:	204-978-1
Product Categories:	Quinolines;Haloquinolines;Hydroxyquinolines;pesticide intermediates;Quinolines, Quinazolines and derivatives;API;130-16-5
Mol File:	130-16-5.mol

5-Chloro-8-hydroxyquinoline Chemical Properties

Melting point	122-124 °C(lit.)
Boiling point	348.7±22.0 °C(Predicted)
density	1.2364 (rough estimate)
vapor pressure	0.003Pa at 25℃
refractive index	1.5330 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	0.019g/l (experimental)
form	Powder
pka	3.77±0.10(Predicted)
color	Light green to gray
Sensitive	Light Sensitive
Merck	14,2422
BRN	5289
InChIKey	RWPWQYXFGFYJBA-UHFFFAOYSA-N
CAS DataBase Reference	130-16-5(CAS DataBase Reference)
NIST Chemistry Reference	8-Quinolinol, 5-chloro-(130-16-5)
EPA Substance Registry System	8-Quinolinol, 5-chloro- (130-16-5)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25
WGK Germany	3
RTECS	VC4590000
TSCA	Yes
HS Code	29334990

MSDS Information

Provider	Language
Cloxiquine	English
SigmaAldrich	English
ACROS	English
ALFA	English

5-Chloro-8-hydroxyquinoline Usage And Synthesis

Chemical Properties	light green to grey powder
Uses	Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
Uses	antibacterial, antifungal
Definition	ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.
Synthesis Reference(s)	The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
in vitro	Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis . Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.\| Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells. Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
in vivo	Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model. Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

5-Chloro-8-hydroxyquinoline Preparation Products And Raw materials

Raw materials	8-Hydroxyquinoline
Preparation Products	1,2,3,4-Tetrahydro-8-hydroxyquinoline-->Quinoline, 5-chloro-8-phenoxy--->5-CHLORO-1,2,3,4-TETRAHYDRO-QUINOLIN-8-OL-->8-Quinolinol, 5-chloro-7-(2-propen-1-yl)-

CHEMBRDG-BB 5175177 6-CHLORO-3-(3,4-DICHLOROBENZYL)-3,4-DIHYDRO-2H-[1,3]OXAZINO[5,6-H]QUINOLINE 5,7-Dichloro-8-quinolinol benzoate (ester) 5-CHLORO-8-QUINOLYL 2-CHLORONICOTINATE 5-CHLORO-4-HYDRAZINO-8-METHOXY-2-METHYLQUINOLINE 5,7-DICHLORO-8-QUINOLYL 2-CHLORONICOTINATE 3-[(5-CHLORO-8-QUINOLINYL)OXY]-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 5,7-Dichloro-8-hydroxyquinaldine ETHYL 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE AKOS BBS-00006295 8-QUINOLINOL, 7-AMINO-5-CHLORO- 7-CHLORO-2-HYDROXYQUINOLINE-3-CARBALDEHYDE 5-CHLORO-7-(MORPHOLIN-4-YLMETHYL)QUINOLIN-8-OL Clamoxyquine 7-CHLORO-4-HYDROXYQUINOLINE,7-CHLORO-4-HYDROXYQUINOLINE, 98+%,7-CHLORO-4-HYDROXYQUINOLINE 97+% 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE 98+%,7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE PEST ANAL,7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE 4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL HYDROGEN PHOSPHATE 4-CHLOROPHENYL-5-CHLORO-8-QUINOLINYL PHOSPHOROCHLORIDATE

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