|
| | Ferrostatin-1 (Fer-1) Basic information |
| Product Name: | Ferrostatin-1 (Fer-1) | | Synonyms: | Ethyl 3-amino-4-(cyclohexylamino)benzoate;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;Ferrostatin-1 (Fer-1);Fer 1;Fer1;Fer-1;FER-1;FER 1;FER1;FERROSTATIN-1;FERROSTATIN 1;FERROSTATIN1 | | CAS: | 347174-05-4 | | MF: | C15H22N2O2 | | MW: | 262.35 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 347174-05-4.mol |  |
| | Ferrostatin-1 (Fer-1) Chemical Properties |
| Boiling point | 437.3±35.0 °C(Predicted) | | density | 1.150±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 4.78±0.11(Predicted) | | form | powder | | color | purple to brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | | InChIKey | UJHBVMHOBZBWMX-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2922498590 |
| | Ferrostatin-1 (Fer-1) Usage And Synthesis |
| Description | Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1?Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1?Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2?Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4. | | Uses | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis. | | Definition | ChEBI: Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. It has a role as a ferroptosis inhibitor, a radiation protective agent, an antioxidant, a radical scavenger, an antifungal agent and a neuroprotective agent. It is a substituted aniline, an ethyl ester and a primary arylamine. | | Biochem/physiol Actions | Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models. | | storage | Store at +4°C | | References | 1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060
2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732
3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551
4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764 |
| | Ferrostatin-1 (Fer-1) Preparation Products And Raw materials |
|
